| Title |
Body mass index and risk of luminal, HER2-overexpressing, and triple negative breast cancer
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, May 2016
|
| DOI | 10.1007/s10549-016-3825-9 |
| Pubmed ID | |
| Authors |
Lu Chen, Linda S. Cook, Mei-Tzu C. Tang, Peggy L. Porter, Deirdre A. Hill, Charles L. Wiggins, Christopher I. Li |
| Abstract |
Triple negative (TN, tumors that do not express estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER2)) and HER2-overexpressing (H2E, ER-/HER2+) tumors are two particularly aggressive subtypes of breast cancer. There is a lack of knowledge regarding the etiologies of these cancers and in particular how anthropometric factors are related to risk. We conducted a population-based case-case study consisting of 2659 women aged 20-69 years diagnosed with invasive breast cancer from 2004 to 2012. Four case groups defined based on joint ER/PR/HER2 status were included: TN, H2E, luminal A (ER+/HER2-), and luminal B (ER+/HER2+). Polytomous logistic regression was used to estimate odds ratios (ORs) and associated 95 % confidence intervals (CIs) where luminal A patients served as the reference group. Obese premenopausal women [body mass index (BMI) ≥30 kg/m(2)] had an 82 % (95 % CI 1.32-2.51) increased risk of TN breast cancer compared to women whose BMI <25 kg/m(2), and those in the highest weight quartile (quartiles were categorized based on the distribution among luminal A patients) had a 79 % (95 % CI 1.23-2.64) increased risk of TN disease compared to those in the lowest quartile. Among postmenopausal women obesity was associated with reduced risks of both TN (OR = 0.74, 95 % CI 0.54-1.00) and H2E (OR = 0.47, 95 % CI 0.32-0.69) cancers. Our results suggest obesity has divergent impacts on risk of aggressive subtypes of breast cancer in premenopausal versus postmenopausal women, which may contribute to the higher incidence rates of TN cancers observed among younger African American and Hispanic women. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 50% |
| United Kingdom | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 94 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 16% |
| Researcher | 13 | 14% |
| Student > Master | 10 | 11% |
| Student > Ph. D. Student | 7 | 7% |
| Other | 5 | 5% |
| Other | 18 | 19% |
| Unknown | 26 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 31% |
| Biochemistry, Genetics and Molecular Biology | 9 | 10% |
| Agricultural and Biological Sciences | 6 | 6% |
| Nursing and Health Professions | 5 | 5% |
| Immunology and Microbiology | 2 | 2% |
| Other | 11 | 12% |
| Unknown | 32 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2016.
All research outputs
#15,380,162
of 22,880,691 outputs
Outputs from Breast Cancer Research and Treatment
#3,299
of 4,659 outputs
Outputs of similar age
#208,127
of 334,095 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#55
of 108 outputs
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