| Title |
Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass
|
|---|---|
| Published in |
Diabetologia, April 2012
|
| DOI | 10.1007/s00125-012-2556-7 |
| Pubmed ID | |
| Authors |
C. Dirksen, N. B. Jørgensen, K. N. Bojsen-Møller, S. H. Jacobsen, D. L. Hansen, D. Worm, J. J. Holst, S. Madsbad |
| Abstract |
Roux-en-Y gastric bypass (RYGB) greatly improves glycaemic control in morbidly obese patients with type 2 diabetes, in many even before significant weight loss. Understanding the responsible mechanisms may contribute to our knowledge of the pathophysiology of type 2 diabetes and help identify new drug targets or improve surgical techniques. This review summarises the present knowledge based on pathophysiological studies published during the last decade. Taken together, two main mechanisms seem to be responsible for the early improvement in glycaemic control after RYGB: (1) an increase in hepatic insulin sensitivity induced, at least in part, by energy restriction and (2) improved beta cell function associated with an exaggerated postprandial glucagon-like peptide 1 secretion owing to the altered transit of nutrients. Later a weight loss induced improvement in peripheral insulin sensitivity follows. |
Mendeley readers
The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Germany | 1 | <1% |
| Unknown | 181 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 18% |
| Student > Bachelor | 27 | 15% |
| Researcher | 26 | 14% |
| Student > Master | 21 | 11% |
| Professor | 10 | 5% |
| Other | 39 | 21% |
| Unknown | 28 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 88 | 48% |
| Agricultural and Biological Sciences | 27 | 15% |
| Biochemistry, Genetics and Molecular Biology | 13 | 7% |
| Nursing and Health Professions | 3 | 2% |
| Immunology and Microbiology | 2 | 1% |
| Other | 10 | 5% |
| Unknown | 41 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2018.
All research outputs
#7,416,987
of 22,679,690 outputs
Outputs from Diabetologia
#2,821
of 5,025 outputs
Outputs of similar age
#53,955
of 163,342 outputs
Outputs of similar age from Diabetologia
#20
of 45 outputs
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