Title |
Medication safety research by observational study design
|
---|---|
Published in |
International Journal of Clinical Pharmacy, March 2016
|
DOI | 10.1007/s11096-016-0285-6 |
Pubmed ID | |
Authors |
Kim S. J. Lao, Celine S. L. Chui, Kenneth K. C. Man, Wallis C. Y. Lau, Esther W. Chan, Ian C. K. Wong |
Abstract |
Observational studies have been recognised to be essential for investigating the safety profile of medications. Numerous observational studies have been conducted on the platform of large population databases, which provide adequate sample size and follow-up length to detect infrequent and/or delayed clinical outcomes. Cohort and case-control are well-accepted traditional methodologies for hypothesis testing, while within-individual study designs are developing and evolving, addressing previous known methodological limitations to reduce confounding and bias. Respective examples of observational studies of different study designs using medical databases are shown. Methodology characteristics, study assumptions, strengths and weaknesses of each method are discussed in this review. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Curaçao | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 72 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 19% |
Researcher | 10 | 14% |
Student > Ph. D. Student | 8 | 11% |
Student > Bachelor | 6 | 8% |
Other | 5 | 7% |
Other | 12 | 17% |
Unknown | 17 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 33% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Sports and Recreations | 4 | 6% |
Nursing and Health Professions | 3 | 4% |
Social Sciences | 3 | 4% |
Other | 14 | 19% |
Unknown | 19 | 26% |