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Mendeley readers
Attention Score in Context
| Title |
Localization of cholesterol, amyloid and glia in Alzheimer’s disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging
|
|---|---|
| Published in |
Acta Neuropathologica, September 2012
|
| DOI | 10.1007/s00401-012-1046-9 |
| Pubmed ID | |
| Authors |
Santiago Solé-Domènech, Peter Sjövall, Vladana Vukojević, Ruani Fernando, Alina Codita, Sachin Salve, Nenad Bogdanović, Abdul H. Mohammed, Per Hammarström, K. Peter R. Nilsson, Frank M. LaFerla, Stefan Jacob, Per-Olof Berggren, Lydia Giménez-Llort, Martin Schalling, Lars Terenius, Björn Johansson |
| Abstract |
The spatial distributions of lipids, amyloid-beta deposits, markers of neurons and glial cells were imaged, at submicrometer lateral resolution, in brain structures of a mouse model of Alzheimer's disease using a new methodology that combines time-of-flight secondary ion mass spectrometry (ToF-SIMS) and confocal fluorescence microscopy. The technology, which enabled us to simultaneously image the lipid and glial cell distributions in Tg2576 mouse brain structures, revealed micrometer-sized cholesterol accumulations in hippocampal regions undergoing amyloid-beta deposition. Such cholesterol granules were either associated with individual amyloid deposits or spread over entire regions undergoing amyloidogenesis. Subsequent immunohistochemical analysis of the same brain regions showed increased microglial and astrocytic immunoreactivity associated with the amyloid deposits, as expected from previous studies, but did not reveal any particular astrocytic or microglial feature correlated with cholesterol granulation. However, dystrophic neurites as well as presynaptic vesicles presented a distribution similar to that of cholesterol granules in regions undergoing amyloid-beta accumulation, thus indicating that these neuronal endpoints may retain cholesterol in areas with lesions. In conclusion, the present study provides evidence for an altered cholesterol distribution near amyloid deposits that would have been missed by several other lipid analysis methods, and opens for the possibility to study in detail the putative liaison between lipid environment and protein structure and function in Alzheimer's disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 2 | 2% |
| United States | 1 | 1% |
| Spain | 1 | 1% |
| Unknown | 89 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 26% |
| Student > Ph. D. Student | 23 | 25% |
| Professor > Associate Professor | 7 | 8% |
| Student > Master | 5 | 5% |
| Student > Doctoral Student | 4 | 4% |
| Other | 15 | 16% |
| Unknown | 15 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 16 | 17% |
| Agricultural and Biological Sciences | 15 | 16% |
| Neuroscience | 12 | 13% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Medicine and Dentistry | 4 | 4% |
| Other | 17 | 18% |
| Unknown | 23 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2012.
All research outputs
#18,316,001
of 22,679,690 outputs
Outputs from Acta Neuropathologica
#2,192
of 2,358 outputs
Outputs of similar age
#129,659
of 170,728 outputs
Outputs of similar age from Acta Neuropathologica
#14
of 17 outputs
Altmetric has tracked 22,679,690 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,358 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,728 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.