Title |
Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects
|
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Published in |
Journal of Medical Genetics, September 2012
|
DOI | 10.1136/jmedgenet-2012-101175 |
Pubmed ID | |
Authors |
Christina M Lill, Tian Liu, Brit-Maren M Schjeide, Johannes T Roehr, Denis A Akkad, Vincent Damotte, Antonio Alcina, Miguel A Ortiz, Rafa Arroyo, Aitzkoa Lopez de Lapuente, Paul Blaschke, Alexander Winkelmann, Lisa-Ann Gerdes, Felix Luessi, Oscar Fernadez, Guillermo Izquierdo, Alfredo Antigüedad, Sabine Hoffjan, Isabelle Cournu-Rebeix, Silvana Gromöller, Hans Faber, Maria Liebsch, Esther Meissner, Coralie Chanvillard, Emmanuel Touze, Fernando Pico, Philippe Corcia, Thomas Dörner, Elisabeth Steinhagen-Thiessen, Lars Baeckman, Hauke R Heekeren, Shu-Chen Li, Ulman Lindenberger, Andrew Chan, Hans-Peter Hartung, Orhan Aktas, Peter Lohse, Tania Kümpfel, Christian Kubisch, Joerg T Epplen, Uwe K Zettl, Bertrand Fontaine, Koen Vandenbroeck, Fuencisla Matesanz, Elena Urcelay, Lars Bertram, Frauke Zipp |
Abstract |
Single nucleotide polymorphisms (SNPs) rs429358 (ε4) and rs7412 (ε2), both invoking changes in the amino-acid sequence of the apolipoprotein E (APOE) gene, have previously been tested for association with multiple sclerosis (MS) risk. However, none of these studies was sufficiently powered to detect modest effect sizes at acceptable type-I error rates. As both SNPs are only imperfectly captured on commonly used microarray genotyping platforms, their evaluation in the context of genome-wide association studies has been hindered until recently. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 7 | 9% |
Nigeria | 3 | 4% |
United Kingdom | 3 | 4% |
Venezuela, Bolivarian Republic of | 2 | 3% |
India | 2 | 3% |
Pakistan | 2 | 3% |
Canada | 2 | 3% |
Russia | 1 | 1% |
Unknown | 55 | 71% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 72 | 94% |
Science communicators (journalists, bloggers, editors) | 3 | 4% |
Scientists | 2 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 4% |
Portugal | 1 | 2% |
Germany | 1 | 2% |
Unknown | 47 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 16% |
Professor | 6 | 12% |
Student > Bachelor | 5 | 10% |
Student > Master | 5 | 10% |
Student > Ph. D. Student | 5 | 10% |
Other | 11 | 22% |
Unknown | 11 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 24% |
Agricultural and Biological Sciences | 10 | 20% |
Neuroscience | 7 | 14% |
Biochemistry, Genetics and Molecular Biology | 6 | 12% |
Computer Science | 1 | 2% |
Other | 2 | 4% |
Unknown | 13 | 25% |