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A Novel Population of Wake-Promoting GABAergic Neurons in the Ventral Lateral Hypothalamus

Overview of attention for article published in Current Biology, July 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

Citations

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Title
A Novel Population of Wake-Promoting GABAergic Neurons in the Ventral Lateral Hypothalamus
Published in
Current Biology, July 2016
DOI 10.1016/j.cub.2016.05.078
Pubmed ID
Authors

Anne Venner, Christelle Anaclet, Rebecca Y. Broadhurst, Clifford B. Saper, Patrick M. Fuller

Abstract

The largest synaptic input to the sleep-promoting ventrolateral preoptic area (VLPO) [1] arises from the lateral hypothalamus [2], a brain area associated with arousal [3-5]. However, the neurochemical identity of the majority of these VLPO-projecting neurons within the lateral hypothalamus (LH), as well as their function in the arousal network, remains unknown. Herein we describe a population of VLPO-projecting neurons in the LH that express the vesicular GABA transporter (VGAT; a marker for GABA-releasing neurons). In addition to the VLPO, these neurons also project to several other established sleep and arousal nodes, including the tuberomammillary nucleus, ventral periaqueductal gray, and locus coeruleus. Selective and acute chemogenetic activation of LH VGAT(+) neurons was profoundly wake promoting, whereas acute inhibition increased sleep. Because of its direct and massive inputs to the VLPO, this population may play a particularly important role in sleep-wake switching.

X Demographics

X Demographics

The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 172 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Uruguay 1 <1%
France 1 <1%
Unknown 170 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 42 24%
Researcher 29 17%
Student > Master 24 14%
Student > Bachelor 14 8%
Student > Doctoral Student 9 5%
Other 24 14%
Unknown 30 17%
Readers by discipline Count As %
Neuroscience 67 39%
Agricultural and Biological Sciences 29 17%
Medicine and Dentistry 14 8%
Psychology 8 5%
Biochemistry, Genetics and Molecular Biology 4 2%
Other 11 6%
Unknown 39 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2018.
All research outputs
#2,441,006
of 25,402,528 outputs
Outputs from Current Biology
#5,220
of 14,694 outputs
Outputs of similar age
#43,027
of 370,929 outputs
Outputs of similar age from Current Biology
#89
of 216 outputs
Altmetric has tracked 25,402,528 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,694 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 61.9. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 370,929 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 216 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.