| Title |
Pharmacokinetics of ranitidine in preterm and term neonates with gastroesophageal reflux
|
|---|---|
| Published in |
BMC Pediatrics, July 2016
|
| DOI | 10.1186/s12887-016-0630-x |
| Pubmed ID | |
| Authors |
Ismael Lares Asseff, Graciela Benitez Gaucin, Hugo Juárez Olguín, Jose Antonio Godinez Nájera, Alejandra Toledo López, Gabriela Pérez Guillé, Fausto Zamura Torres |
| Abstract |
The aim of this study was to determine the effect of gestational age on pharmacokinetics of ranitidine in newborns with gastroesophageal reflux. A prospective, descriptive and pharmacokinetic study was carried out in 30 pre-term and 20 full-term babies. 3 mg/kg of ranitidine was administered intravenously to all the babies and at 0.25, 0.5, 1, 2, 4, and 8 h following the administration, samples of blood were drawn to assess ranitidine levels using high performance liquid chromatographic technique. Pharmacokinetics of ranitidine had a bi-exponential behavior with a half-life elimination of (t1/2el) 2.79 h, area under curve (AUC) of 1688 ng/mL, volume of distribution (Vd) of 1.44 L/kg, and clearance (Cl) of 5.9 L/kg/h. The median plasmatic concentration in pre-terms was 1113 ng/mL and 280 ng/mL in full-terms. Vd, t1/2 and Cl presented high values in preterm although the correlation of Cl with glomerular filtration in term newborns was better. Plasma levels of ranitidine depend on the gestational age of the newborns. However, the possible relationship between after-birth age and pharmacokinetics of the neonates as their internal organs get matured without minding their gestational background. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 6 | 21% |
| Student > Master | 5 | 17% |
| Student > Bachelor | 3 | 10% |
| Researcher | 3 | 10% |
| Student > Ph. D. Student | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 10 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 38% |
| Nursing and Health Professions | 3 | 10% |
| Psychology | 2 | 7% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Neuroscience | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 11 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2016.
All research outputs
#14,857,184
of 22,880,691 outputs
Outputs from BMC Pediatrics
#1,913
of 3,012 outputs
Outputs of similar age
#216,454
of 354,681 outputs
Outputs of similar age from BMC Pediatrics
#29
of 51 outputs
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We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.