| Title |
Insights into APC/C: from cellular function to diseases and therapeutics
|
|---|---|
| Published in |
Cell Division, July 2016
|
| DOI | 10.1186/s13008-016-0021-6 |
| Pubmed ID | |
| Authors |
Zhuan Zhou, Mingjing He, Anil A. Shah, Yong Wan |
| Abstract |
Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as cell division, differentiation, genome stability, energy metabolism, cell death, autophagy as well as carcinogenesis. Activity of APC/C is principally governed by two WD-40 domain proteins, Cdc20 and Cdh1, in and beyond cell cycle. In the past decade, the results based on numerous biochemical, 3D structural, mouse genetic and small molecule inhibitor studies have largely attracted our attention into the emerging role of APC/C and its regulation in biological function, human diseases and potential therapeutics. This review will aim to summarize some recently reported insights into APC/C in regulating cellular function, connection of its dysfunction with human diseases and its implication of therapeutics. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| Unknown | 170 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 19% |
| Student > Master | 24 | 14% |
| Researcher | 22 | 13% |
| Student > Bachelor | 22 | 13% |
| Student > Doctoral Student | 11 | 6% |
| Other | 13 | 8% |
| Unknown | 47 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 59 | 35% |
| Agricultural and Biological Sciences | 29 | 17% |
| Medicine and Dentistry | 9 | 5% |
| Neuroscience | 7 | 4% |
| Immunology and Microbiology | 3 | 2% |
| Other | 12 | 7% |
| Unknown | 52 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2016.
All research outputs
#14,857,184
of 22,880,691 outputs
Outputs from Cell Division
#71
of 131 outputs
Outputs of similar age
#216,454
of 354,681 outputs
Outputs of similar age from Cell Division
#1
of 3 outputs
Altmetric has tracked 22,880,691 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 131 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
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We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them