Title |
Expression of human selenoprotein genes selh, selk, selm, sels, selv, and gpx-6 in various tumor cell lines
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Published in |
Doklady Biochemistry and Biophysics, July 2016
|
DOI | 10.1134/s1607672916030121 |
Pubmed ID | |
Authors |
E. G. Varlamova, M. V. Goltyaev, E. E. Fesenko |
Abstract |
The expression level of the genes encoding six selenocysteine-containing human proteins was determined in the brain, cervical, liver, breast, prostate, and human fibrosarcoma cancer cells. It was found that a high level of expression in all studied types genes of tumor cells is characteristic for selh, selk, and selm genes, encoding SelH, SelK, and SelM proteins, respectively, whereas a complete lack of such expression was shown for gpx-6, selv, and sels genes. The results of this work can be regarded as a major prerequisite for further studies on the role of the three selenoproteins SelH, SelK, and SelM in the regulation of carcinogenesis processes associated with these types of cancer. |
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