| Title |
Synthesis and Characterization of Nanocomposite Microparticles (nCmP) for the Treatment of Cystic Fibrosis-Related Infections
|
|---|---|
| Published in |
Pharmaceutical Research, April 2016
|
| DOI | 10.1007/s11095-016-1921-5 |
| Pubmed ID | |
| Authors |
Zimeng Wang, Samantha A. Meenach |
| Abstract |
Pulmonary antibiotic delivery is recommended as maintenance therapy for cystic fibrosis (CF) patients who experience chronic infections. However, abnormally thick and sticky mucus present in the respiratory tract of CF patients impairs mucus penetration and limits the efficacy of inhaled antibiotics. To overcome the obstacles of pulmonary antibiotic delivery, we have developed nanocomposite microparticles (nCmP) for the inhalation application of antibiotics in the form of dry powder aerosols. Azithromycin-loaded and rapamycin-loaded polymeric nanoparticles (NP) were prepared via nanoprecipitation and nCmP were prepared by spray drying and the physicochemical characteristics were evaluated. The nanoparticles were 200 nm in diameter both before loading into and after redispersion from nCmP. The NP exhibited smooth, spherical morphology and the nCmP were corrugated spheres about 1 μm in diameter. Both drugs were successfully encapsulated into the NP and were released in a sustained manner. The NP were successfully loaded into nCmP with favorable encapsulation efficacy. All materials were stable at manufacturing and storage conditions and nCmP were in an amorphous state after spray drying. nCmP demonstrated desirable aerosol dispersion characteristics, allowing them to deposit into the deep lung regions for effective drug delivery. The described nCmP have the potential to overcome mucus-limited pulmonary delivery of antibiotics. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 21% |
| Student > Ph. D. Student | 6 | 16% |
| Student > Bachelor | 5 | 13% |
| Other | 2 | 5% |
| Student > Postgraduate | 2 | 5% |
| Other | 4 | 11% |
| Unknown | 11 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 26% |
| Biochemistry, Genetics and Molecular Biology | 2 | 5% |
| Materials Science | 2 | 5% |
| Chemical Engineering | 2 | 5% |
| Agricultural and Biological Sciences | 1 | 3% |
| Other | 8 | 21% |
| Unknown | 13 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2016.
All research outputs
#18,465,988
of 22,880,691 outputs
Outputs from Pharmaceutical Research
#2,480
of 2,860 outputs
Outputs of similar age
#219,060
of 299,135 outputs
Outputs of similar age from Pharmaceutical Research
#30
of 43 outputs
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