Title |
The relationship between HBcrAg and HBV reinfection in HBV related post-liver transplantation patients
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Published in |
Journal of Gastroenterology, July 2016
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DOI | 10.1007/s00535-016-1240-y |
Pubmed ID | |
Authors |
Ayako Urabe, Michio Imamura, Masataka Tsuge, Hiromi Kan, Hatsue Fujino, Takayuki Fukuhara, Keiichi Masaki, Tomoki Kobayashi, Atsushi Ono, Takashi Nakahara, Tomokazu Kawaoka, Akira Hiramatsu, Yoshiiku Kawakami, Hiroshi Aikata, Clair Nelson Hayes, Noboru Maki, Hideaki Ohdan, Kazuaki Chayama |
Abstract |
Post-transplant hepatitis B virus (HBV) reinfection is one of the major problems facing patients who undergo HBV-related liver transplantation (LT). We analyzed the clinical impact of serum hepatitis B core-related antigen (HBcrAg) on HBV reinfection in post-LT patients with HBV-related liver diseases. Serum hepatitis B surface antigen (HBsAg), HBV DNA, and HBcrAg were measured over time in 32 post-LT patients. Twenty-one out of 32 patients had HCC at LT. The effects of HBcrAg, hepatocellular carcinoma (HCC) recurrence, and HBs gene mutation on HBV reinfection and withdrawal from hepatitis B immune globulin (HBIG) were analyzed. Sixteen out of 32 patients (50 %) were positive for HBcrAg even though only six patients were thought to have experienced HBV reinfection based on reappearance of either HBV DNA or HBsAg during a median follow-up time of 75 months. Three of these six patients who became re-infected with HBV experienced HCC recurrence after LT. The HBV DNA reappearance rate was significantly higher in patients with HCC recurrence after LT (p < 0.001). Two HBV re-infected patients without HCC recurrence had HBs gene mutations G145R and G145A, respectively. Anti-HBs antibody development rate by HB vaccination was similar between HBcrAg-positive and negative patients (p = 0.325). HBV reinfection is more common than is usually considered based on conventional measurement of HBsAg and HBV DNA. HCC recurrence and mutations in the HBV S gene were associated with HBV reinfection after LT. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 16% |
Other | 3 | 10% |
Student > Postgraduate | 3 | 10% |
Student > Master | 3 | 10% |
Student > Bachelor | 2 | 6% |
Other | 9 | 29% |
Unknown | 6 | 19% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 13 | 42% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Agricultural and Biological Sciences | 3 | 10% |
Environmental Science | 1 | 3% |
Unknown | 10 | 32% |