| Title |
Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration
|
|---|---|
| Published in |
Molecular Neurobiology, August 2008
|
| DOI | 10.1007/s12035-008-8036-x |
| Pubmed ID | |
| Authors |
P. S. Vosler, C. S. Brennan, J. Chen |
| Abstract |
Calpain is a ubiquitous calcium-sensitive protease that is essential for normal physiologic neuronal function. However, alterations in calcium homeostasis lead to persistent, pathologic activation of calpain in a number of neurodegenerative diseases. Pathologic activation of calpain results in the cleavage of a number of neuronal substrates that negatively affect neuronal structure and function, leading to inhibition of essential neuronal survival mechanisms. In this review, we examine the mechanistic underpinnings of calcium dysregulation resulting in calpain activation in the acute neurodegenerative diseases such as cerebral ischemia and in the chronic neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, prion-related encephalopathy, and amylotrophic lateral sclerosis. The premise of this paper is that analysis of the signaling and transcriptional consequences of calpain-mediated cleavage of its various substrates for any neurodegenerative disease can be extrapolated to all of the neurodegenerative diseases vulnerable to calcium dysregulation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 243 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 1% |
| United Kingdom | 3 | 1% |
| Portugal | 2 | <1% |
| India | 1 | <1% |
| Chile | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| Greece | 1 | <1% |
| United States | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 228 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 60 | 25% |
| Student > Master | 43 | 18% |
| Researcher | 38 | 16% |
| Student > Bachelor | 19 | 8% |
| Student > Doctoral Student | 13 | 5% |
| Other | 42 | 17% |
| Unknown | 28 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 70 | 29% |
| Neuroscience | 45 | 19% |
| Biochemistry, Genetics and Molecular Biology | 31 | 13% |
| Medicine and Dentistry | 31 | 13% |
| Psychology | 7 | 3% |
| Other | 24 | 10% |
| Unknown | 35 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2023.
All research outputs
#2,920,568
of 22,679,690 outputs
Outputs from Molecular Neurobiology
#470
of 3,428 outputs
Outputs of similar age
#8,789
of 82,415 outputs
Outputs of similar age from Molecular Neurobiology
#2
of 6 outputs
Altmetric has tracked 22,679,690 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,428 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 82,415 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.