| Title |
Differential effect of treadmill exercise on histone deacetylase activity in rat striatum at different stages of development
|
|---|---|
| Published in |
The Journal of Physiological Sciences, July 2016
|
| DOI | 10.1007/s12576-016-0471-2 |
| Pubmed ID | |
| Authors |
Viviane Rostirola Elsner, Carla Basso, Karine Bertoldi, Louisiana Carolina Ferreira de Meireles, Laura Reck Cechinel, Ionara Rodrigues Siqueira |
| Abstract |
The study described herein aimed to evaluate the impact of exercise on histone acetylation markers in striatum from Wistar rats at different stages of development. Male Wistar rats were submitted to two different exercise protocols: a single session of treadmill (running 20 min) or a moderate daily exercise protocol (running 20 min for 2 weeks). Striata of rats aged 39 days postnatal (adolescents), 3 months (young adults), and 20 months (aged) were used. The single exercise session induced persistent effects on global HDAC activity only in the adolescent group, given that exercised rats showed decreased HDAC activity 1 and 18 h after training, without effect on histone H4 acetylation levels. However, the moderate daily exercise did not alter any histone acetylation marker in adolescent and mature groups in any time point evaluated after training. In sum, our data suggest that exercise impacts striatal HDAC activity in an age- and protocol-dependent manner. Specifically, this response seems to be more evident during the adolescent period and might suffer a molecular adaptation in response to chronic training. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 15% |
| Researcher | 3 | 12% |
| Student > Ph. D. Student | 3 | 12% |
| Student > Postgraduate | 2 | 8% |
| Student > Bachelor | 2 | 8% |
| Other | 5 | 19% |
| Unknown | 7 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 5 | 19% |
| Biochemistry, Genetics and Molecular Biology | 4 | 15% |
| Sports and Recreations | 4 | 15% |
| Medicine and Dentistry | 3 | 12% |
| Agricultural and Biological Sciences | 2 | 8% |
| Other | 2 | 8% |
| Unknown | 6 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2016.
All research outputs
#19,495,804
of 23,975,976 outputs
Outputs from The Journal of Physiological Sciences
#221
of 321 outputs
Outputs of similar age
#278,572
of 360,234 outputs
Outputs of similar age from The Journal of Physiological Sciences
#7
of 10 outputs
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