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Mendeley readers
Attention Score in Context
| Title |
Delays during the administration of acetylcysteine for the treatment of paracetamol overdose
|
|---|---|
| Published in |
British Journal of Clinical Pharmacology, August 2016
|
| DOI | 10.1111/bcp.13063 |
| Pubmed ID | |
| Authors |
George P. Bailey, Javad Najafi, Muhammad E. M. O. Elamin, W. Stephen Waring, Simon H. L. Thomas, John R. H. Archer, David M. Wood, Paul I. Dargan |
| Abstract |
The licensed intravenous acetylcysteine regimen for treating paracetamol overdose in most countries uses three separate infusions over 21 hours. This complex regimen, requiring different infusion concentrations and rates, has been associated with administration errors. The aim was to assess the extent of administration delays occurring during this acetylcysteine regimen. A 6-month retrospective observational study was conducted at three English teaching hospitals with clinical toxicology services from October 2014. Patients aged 16-years and over treated with intravenous acetylcysteine for paracetamol overdose were included. The start times for infusions were recorded and the delays compared to the prescribed infusion times were calculated. Anaphylactoid reactions, intravenous cannula problems, overdose intent and smoking status were recorded to assess their contribution to delays. From 263 cases identified, 198 met study inclusion criteria. The median time between the start of infusions 1 and 3 was delayed from the intended 5 hours by a median (IQR) of 90 (50-163) minutes, with 135 (68%) cases delayed by more than one hour. Significantly longer delays were observed in patients with anaphylactoid reactions (median delay 267 (217-413) minutes, n = 8) and accidental / supra-therapeutic overdose (median delay 170 (95-260) minutes, n = 29). There were no significant differences between smokers and non-smokers and for patients with intravenous cannula problems. Long delays were identified during the three-infusion acetylcysteine regimen for the treatment of paracetamol overdose. Delays were of clinical significance and could lead to periods of sub-therapeutic plasma acetylcysteine concentrations and potentially avoidable hepatotoxicity, as well as delaying hospital discharge. |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 12% |
| Student > Bachelor | 4 | 12% |
| Professor | 3 | 9% |
| Student > Doctoral Student | 3 | 9% |
| Researcher | 3 | 9% |
| Other | 9 | 27% |
| Unknown | 7 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 42% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 9% |
| Nursing and Health Professions | 2 | 6% |
| Sports and Recreations | 2 | 6% |
| Business, Management and Accounting | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 10 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#3,237,958
of 24,417,958 outputs
Outputs from British Journal of Clinical Pharmacology
#849
of 5,365 outputs
Outputs of similar age
#57,315
of 364,941 outputs
Outputs of similar age from British Journal of Clinical Pharmacology
#19
of 51 outputs
Altmetric has tracked 24,417,958 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,365 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 364,941 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.