| Title |
TRPV1 activation prevents nonalcoholic fatty liver through UCP2 upregulation in mice
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, March 2012
|
| DOI | 10.1007/s00424-012-1078-y |
| Pubmed ID | |
| Authors |
Li Li, Jing Chen, Yinxing Ni, Xiaoli Feng, Zhigang Zhao, Peijian Wang, Jing Sun, Hao Yu, Zhencheng Yan, Daoyan Liu, Bernd Nilius, Zhiming Zhu |
| Abstract |
Nonalcoholic fatty liver is characterized by the fatty deformation and lipid deposition of hepatic parenchymal cells that are associated with cardiometabolic diseases. In this study, we report the effect of capsaicin on its receptor, transient receptor potential vanilloid 1 (TRPV1) cation channel, in preventing fatty liver formation. Functional TRPV1 has been detected in hepatocytes and liver tissues. TRPV1 activation by capsaicin reduced lipid accumulation and triglyceride level in the liver from wild-type (WT) mice. However, these effects were absent in the liver from TRPV1(-/-) mice. Chronic dietary capsaicin increased the hepatic uncoupling protein 2 (UCP2) expression in WT but not in TRPV1(-/-) mice (P < 0.01). We conclude that TRPV1 long-time activation might prevent high-fat diet-induced fatty liver in mice through upregulation of hepatic UCP2. Dietary capsaicin may represent a promising intervention in populations at high risk for fatty liver. |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| Chile | 1 | 2% |
| Unknown | 54 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 23% |
| Student > Ph. D. Student | 8 | 14% |
| Student > Bachelor | 6 | 11% |
| Professor | 5 | 9% |
| Student > Master | 5 | 9% |
| Other | 8 | 14% |
| Unknown | 11 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 25% |
| Biochemistry, Genetics and Molecular Biology | 14 | 25% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Medicine and Dentistry | 3 | 5% |
| Neuroscience | 2 | 4% |
| Other | 4 | 7% |
| Unknown | 16 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2014.
All research outputs
#5,567,090
of 25,870,142 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#249
of 2,074 outputs
Outputs of similar age
#34,413
of 169,422 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#1
of 6 outputs
Altmetric has tracked 25,870,142 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,074 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 87% of its peers.
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We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them