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Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes

Overview of attention for article published in Diabetes, November 2012
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

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2 news outlets
blogs
1 blog
twitter
15 X users
facebook
1 Facebook page

Citations

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335 Dimensions

Readers on

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309 Mendeley
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Title
Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes
Published in
Diabetes, November 2012
DOI 10.2337/db11-1653
Pubmed ID
Authors

Marloes Dekker Nitert, Tasnim Dayeh, Peter Volkov, Targ Elgzyri, Elin Hall, Emma Nilsson, Beatrice T. Yang, Stefan Lang, Hemang Parikh, Ylva Wessman, Holger Weishaupt, Joanne Attema, Mia Abels, Nils Wierup, Peter Almgren, Per-Anders Jansson, Tina Rönn, Ola Hansson, Karl-Fredrik Eriksson, Leif Groop, Charlotte Ling

Abstract

To identify epigenetic patterns, which may predispose to type 2 diabetes (T2D) due to a family history (FH) of the disease, we analyzed DNA methylation genome-wide in skeletal muscle from individuals with (FH(+)) or without (FH(-)) an FH of T2D. We found differential DNA methylation of genes in biological pathways including mitogen-activated protein kinase (MAPK), insulin, and calcium signaling (P ≤ 0.007) and of individual genes with known function in muscle, including MAPK1, MYO18B, HOXC6, and the AMP-activated protein kinase subunit PRKAB1 in skeletal muscle of FH(+) compared with FH(-) men. We further validated our findings from FH(+) men in monozygotic twin pairs discordant for T2D, and 40% of 65 analyzed genes exhibited differential DNA methylation in muscle of both FH(+) men and diabetic twins. We further examined if a 6-month exercise intervention modifies the genome-wide DNA methylation pattern in skeletal muscle of the FH(+) and FH(-) individuals. DNA methylation of genes in retinol metabolism and calcium signaling pathways (P < 3 × 10(-6)) and with known functions in muscle and T2D including MEF2A, RUNX1, NDUFC2, and THADA decreased after exercise. Methylation of these human promoter regions suppressed reporter gene expression in vitro. In addition, both expression and methylation of several genes, i.e., ADIPOR1, BDKRB2, and TRIB1, changed after exercise. These findings provide new insights into how genetic background and environment can alter the human epigenome.

X Demographics

X Demographics

The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 309 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 <1%
Portugal 1 <1%
France 1 <1%
Australia 1 <1%
Brazil 1 <1%
Switzerland 1 <1%
Sweden 1 <1%
New Zealand 1 <1%
Iran, Islamic Republic of 1 <1%
Other 1 <1%
Unknown 297 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 69 22%
Student > Master 39 13%
Researcher 37 12%
Student > Bachelor 37 12%
Student > Postgraduate 16 5%
Other 52 17%
Unknown 59 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 65 21%
Agricultural and Biological Sciences 55 18%
Medicine and Dentistry 42 14%
Sports and Recreations 18 6%
Nursing and Health Professions 15 5%
Other 42 14%
Unknown 72 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2023.
All research outputs
#1,272,293
of 25,500,206 outputs
Outputs from Diabetes
#476
of 9,716 outputs
Outputs of similar age
#7,544
of 192,414 outputs
Outputs of similar age from Diabetes
#7
of 96 outputs
Altmetric has tracked 25,500,206 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,716 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,414 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.