Title |
Stabilizing synthetic data in the DNA of living organisms
|
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Published in |
Systems and Synthetic Biology, December 2008
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DOI | 10.1007/s11693-008-9020-5 |
Pubmed ID | |
Authors |
Nozomu Yachie, Yoshiaki Ohashi, Masaru Tomita |
Abstract |
Data-encoding synthetic DNA, inserted into the genome of a living organism, is thought to be more robust than the current media. Because the living genome is duplicated and copied into new generations, one of the merits of using DNA material is long-term data storage within heritable media. A disadvantage of this approach is that encoded data can be unexpectedly broken by mutation, deletion, and insertion of DNA, which occurs naturally during evolution and prolongation, or laboratory experiments. For this reason, several information theory-based approaches have been developed as an error check of broken DNA data in order to achieve data durability. These approaches cannot efficiently recover badly damaged data-encoding DNA. We recently developed a DNA data-storage approach based on the multiple sequence alignment method to achieve a high level of data durability. In this paper, we overview this technology and discuss strategies for optimal application of this approach. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 5% |
Hong Kong | 1 | 2% |
Malaysia | 1 | 2% |
United Kingdom | 1 | 2% |
India | 1 | 2% |
Unknown | 36 | 86% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 21% |
Student > Master | 7 | 17% |
Student > Ph. D. Student | 6 | 14% |
Other | 3 | 7% |
Professor | 3 | 7% |
Other | 7 | 17% |
Unknown | 7 | 17% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 10 | 24% |
Biochemistry, Genetics and Molecular Biology | 6 | 14% |
Engineering | 5 | 12% |
Computer Science | 4 | 10% |
Arts and Humanities | 3 | 7% |
Other | 7 | 17% |
Unknown | 7 | 17% |