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Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

Overview of attention for article published in Angewandte Chemie. International Edition, October 2012
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3 X users
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1 Facebook page

Citations

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55 Dimensions

Readers on

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47 Mendeley
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1 CiteULike
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Title
Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300
Published in
Angewandte Chemie. International Edition, October 2012
DOI 10.1002/anie.201206815
Pubmed ID
Authors

Chinmay Y. Majmudar, Jonas W. Højfeldt, Carl J. Arevang, William C. Pomerantz, Jessica K. Gagnon, Pamela J. Schultz, Laura C. Cesa, Conor H. Doss, Steven P. Rowe, Victor Vásquez, Giselle Tamayo‐Castillo, Tomasz Cierpicki, Charles L. Brooks, David H. Sherman, Anna K. Mapp

Abstract

Capturing a coactivator, naturally: the natural products sekikaic acid and lobaric acid, isolated after a high-throughput screen of a structurally diverse extract collection, effectively target the dynamic binding interfaces of the GACKIX domain of the coactivator CBP/p300. These molecules are the most effective inhibitors of the GACKIX domain yet described and are uniquely selective for this domain.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 46 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 23%
Researcher 7 15%
Other 4 9%
Student > Doctoral Student 3 6%
Professor > Associate Professor 3 6%
Other 8 17%
Unknown 11 23%
Readers by discipline Count As %
Chemistry 23 49%
Biochemistry, Genetics and Molecular Biology 4 9%
Agricultural and Biological Sciences 4 9%
Computer Science 2 4%
Unspecified 1 2%
Other 2 4%
Unknown 11 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2013.
All research outputs
#15,184,741
of 25,394,764 outputs
Outputs from Angewandte Chemie. International Edition
#33,366
of 50,044 outputs
Outputs of similar age
#111,198
of 192,302 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#368
of 696 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 50,044 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,302 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 696 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.