| Title |
Lactation is associated with altered metabolomic signatures in women with gestational diabetes
|
|---|---|
| Published in |
Diabetologia, July 2016
|
| DOI | 10.1007/s00125-016-4055-8 |
| Pubmed ID | |
| Authors |
Daniela Much, Andreas Beyerlein, Alida Kindt, Jan Krumsiek, Ferdinand Stückler, Michaela Rossbauer, Anna Hofelich, David Wiesenäcker, Susanne Hivner, Melanie Herbst, Werner Römisch-Margl, Cornelia Prehn, Jerzy Adamski, Gabi Kastenmüller, Fabian Theis, Anette-G. Ziegler, Sandra Hummel |
| Abstract |
Lactation for >3 months in women with gestational diabetes is associated with a reduced risk of type 2 diabetes that persists for up to 15 years postpartum. However, the underlying mechanisms are unknown. We examined whether in women with gestational diabetes lactation for >3 months is associated with altered metabolomic signatures postpartum. We enrolled 197 women with gestational diabetes at a median of 3.6 years (interquartile range 0.7-6.5 years) after delivery. Targeted metabolomics profiles (including 156 metabolites) were obtained during a glucose challenge test. Comparisons of metabolite concentrations and ratios between women who lactated for >3 months and women who lactated for ≤3 months or not at all were performed using linear regression with adjustment for age and BMI at the postpartum visit, time since delivery, and maternal education level, and correction for multiple testing. Gaussian graphical modelling was used to generate metabolite networks. Lactation for >3 months was associated with a higher total lysophosphatidylcholine/total phosphatidylcholine ratio; in women with short-term follow-up, it was also associated with lower leucine concentrations and a lower total branched-chain amino acid concentration. Gaussian graphical modelling identified subgroups of closely linked metabolites within phosphatidylcholines and branched-chain amino acids that were affected by lactation for >3 months and have been linked to the pathophysiology of type 2 diabetes in previous studies. Lactation for >3 months in women with gestational diabetes is associated with changes in the metabolomics profile that have been linked to the early pathogenesis of type 2 diabetes. |
X Demographics
The data shown below were collected from the profiles of 279 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 107 | 38% |
| United Kingdom | 11 | 4% |
| United States | 10 | 4% |
| Mexico | 5 | 2% |
| Canada | 4 | 1% |
| United Arab Emirates | 4 | 1% |
| Kuwait | 4 | 1% |
| Netherlands | 2 | <1% |
| Australia | 2 | <1% |
| Other | 11 | 4% |
| Unknown | 119 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 229 | 82% |
| Practitioners (doctors, other healthcare professionals) | 29 | 10% |
| Scientists | 17 | 6% |
| Science communicators (journalists, bloggers, editors) | 2 | <1% |
| Unknown | 2 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Unknown | 72 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 15% |
| Student > Master | 10 | 14% |
| Researcher | 9 | 12% |
| Student > Doctoral Student | 8 | 11% |
| Student > Bachelor | 5 | 7% |
| Other | 8 | 11% |
| Unknown | 22 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 21% |
| Biochemistry, Genetics and Molecular Biology | 9 | 12% |
| Agricultural and Biological Sciences | 6 | 8% |
| Nursing and Health Professions | 4 | 5% |
| Computer Science | 2 | 3% |
| Other | 9 | 12% |
| Unknown | 28 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 352. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2019.
All research outputs
#93,368
of 25,769,258 outputs
Outputs from Diabetologia
#70
of 5,448 outputs
Outputs of similar age
#1,958
of 375,264 outputs
Outputs of similar age from Diabetologia
#5
of 77 outputs
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