| Title |
Anterior insula degeneration in frontotemporal dementia
|
|---|---|
| Published in |
Brain Structure and Function, May 2010
|
| DOI | 10.1007/s00429-010-0263-z |
| Pubmed ID | |
| Authors |
William W. Seeley |
| Abstract |
The human anterior insula is anatomically and functionally heterogeneous, containing key nodes within distributed speech-language and viscero-autonomic/social-emotional networks. The frontotemporal dementias selectively target these large-scale systems, leading to at least three distinct clinical syndromes. Examining these disorders, researchers have begun to dissect functions which rely on specific insular nodes and networks. In the behavioral variant of frontotemporal dementia, early-stage frontoinsular degeneration begets progressive "Salience Network" breakdown that leaves patients unable to model the emotional impact of their own actions or inactions. Ongoing studies seek to clarify local microcircuit- and cellular-level factors that confer selective frontoinsular vulnerability. The search for frontotemporal dementia treatments will depend on a rich understanding of insular biology and could help clarify specialized human language, social, and emotional functions. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Singapore | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 288 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 3% |
| Canada | 3 | 1% |
| Netherlands | 2 | <1% |
| United Kingdom | 2 | <1% |
| Italy | 2 | <1% |
| Czechia | 1 | <1% |
| India | 1 | <1% |
| Spain | 1 | <1% |
| Brazil | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 265 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 62 | 22% |
| Researcher | 58 | 20% |
| Student > Master | 28 | 10% |
| Other | 22 | 8% |
| Student > Postgraduate | 19 | 7% |
| Other | 71 | 25% |
| Unknown | 28 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 73 | 25% |
| Neuroscience | 62 | 22% |
| Medicine and Dentistry | 61 | 21% |
| Agricultural and Biological Sciences | 27 | 9% |
| Mathematics | 4 | 1% |
| Other | 15 | 5% |
| Unknown | 46 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2022.
All research outputs
#3,572,274
of 25,381,151 outputs
Outputs from Brain Structure and Function
#273
of 1,964 outputs
Outputs of similar age
#13,924
of 105,017 outputs
Outputs of similar age from Brain Structure and Function
#18
of 24 outputs
Altmetric has tracked 25,381,151 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,964 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 105,017 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.