Title |
miR-EdiTar: a database of predicted A-to-I edited miRNA target sites
|
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Published in |
Bioinformatics, October 2012
|
DOI | 10.1093/bioinformatics/bts589 |
Pubmed ID | |
Authors |
Alessandro Laganà, Alessio Paone, Dario Veneziano, Luciano Cascione, Pierluigi Gasparini, Stefania Carasi, Francesco Russo, Giovanni Nigita, Valentina Macca, Rosalba Giugno, Alfredo Pulvirenti, Dennis Shasha, Alfredo Ferro, Carlo M. Croce |
Abstract |
A-to-I RNA editing is an important mechanism that consists of the conversion of specific adenosines into inosines in RNA molecules. Its dysregulation has been associated to several human diseases including cancer. Recent work has demonstrated a role for A-to-I editing in microRNA (miRNA)-mediated gene expression regulation. In fact, edited forms of mature miRNAs can target sets of genes that differ from the targets of their unedited forms. The specific deamination of mRNAs can generate novel binding sites in addition to potentially altering existing ones. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Canada | 1 | 33% |
France | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Hong Kong | 2 | 4% |
United States | 2 | 4% |
Czechia | 1 | 2% |
Germany | 1 | 2% |
Unknown | 42 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 40% |
Student > Ph. D. Student | 9 | 19% |
Student > Bachelor | 6 | 13% |
Professor > Associate Professor | 5 | 10% |
Other | 3 | 6% |
Other | 5 | 10% |
Unknown | 1 | 2% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 28 | 58% |
Biochemistry, Genetics and Molecular Biology | 11 | 23% |
Computer Science | 2 | 4% |
Medicine and Dentistry | 2 | 4% |
Psychology | 1 | 2% |
Other | 2 | 4% |
Unknown | 2 | 4% |