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Mendeley readers
Attention Score in Context
| Title |
A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25
|
|---|---|
| Published in |
Nature Genetics, September 2010
|
| DOI | 10.1038/ng.664 |
| Pubmed ID | |
| Authors |
Pirro G Hysi, Terri L Young, David A Mackey, Toby Andrew, Alberto Fernández-Medarde, Abbas M Solouki, Alex W Hewitt, Stuart Macgregor, Johannes R Vingerling, Yi-Ju Li, M Kamran Ikram, Lee Yiu Fai, Pak C Sham, Lara Manyes, Angel Porteros, Margarida C Lopes, Francis Carbonaro, Samantha J Fahy, Nicholas G Martin, Cornelia M van Duijn, Timothy D Spector, Jugnoo S Rahi, Eugenio Santos, Caroline C W Klaver, Christopher J Hammond |
| Abstract |
Myopia and hyperopia are at opposite ends of the continuum of refraction, the measure of the eye's ability to focus light, which is an important cause of visual impairment (when aberrant) and is a highly heritable trait. We conducted a genome-wide association study for refractive error in 4,270 individuals from the TwinsUK cohort. We identified SNPs on 15q25 associated with refractive error (rs8027411, P = 7.91 × 10⁻⁸). We replicated this association in six adult cohorts of European ancestry with a combined 13,414 individuals (combined P = 2.07 × 10⁻⁹). This locus overlaps the transcription initiation site of RASGRF1, which is highly expressed in neurons and retina and has previously been implicated in retinal function and memory consolidation. Rasgrf1(-/-) mice show a heavier average crystalline lens (P = 0.001). The identification of a susceptibility locus for refractive error on 15q25 will be important in characterizing the molecular mechanism responsible for the most common cause of visual impairment. |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| United States | 2 | 2% |
| Japan | 2 | 2% |
| Italy | 1 | <1% |
| India | 1 | <1% |
| Australia | 1 | <1% |
| Germany | 1 | <1% |
| Finland | 1 | <1% |
| Unknown | 117 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 37 | 29% |
| Student > Ph. D. Student | 13 | 10% |
| Student > Bachelor | 11 | 9% |
| Other | 10 | 8% |
| Student > Master | 10 | 8% |
| Other | 34 | 26% |
| Unknown | 14 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 35% |
| Agricultural and Biological Sciences | 28 | 22% |
| Biochemistry, Genetics and Molecular Biology | 17 | 13% |
| Physics and Astronomy | 6 | 5% |
| Computer Science | 3 | 2% |
| Other | 14 | 11% |
| Unknown | 16 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2020.
All research outputs
#1,407,867
of 25,837,817 outputs
Outputs from Nature Genetics
#2,126
of 7,639 outputs
Outputs of similar age
#4,550
of 107,850 outputs
Outputs of similar age from Nature Genetics
#10
of 52 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,639 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.7. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 107,850 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.