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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients
|
|---|---|
| Published in |
Radiotherapy & Oncology, July 2016
|
| DOI | 10.1016/j.radonc.2016.06.017 |
| Pubmed ID | |
| Authors |
Christian Nicolaj Andreassen, Barry S. Rosenstein, Sarah L. Kerns, Harry Ostrer, Dirk De Ruysscher, Jamie A. Cesaretti, Gillian C. Barnett, Alison M. Dunning, Leila Dorling, Catharine M.L. West, Neil G. Burnet, Rebecca Elliott, Charlotte Coles, Emma Hall, Laura Fachal, Ana Vega, Antonio Gómez-Caamaño, Christopher J. Talbot, R. Paul Symonds, Kim De Ruyck, Hubert Thierens, Piet Ost, Jenny Chang-Claude, Petra Seibold, Odilia Popanda, Marie Overgaard, David Dearnaley, Matthew R. Sydes, David Azria, Christine Anne Koch, Matthew Parliament, Michael Blackshaw, Michael Sia, Maria J. Fuentes-Raspall, Teresa Ramon y Cajal, Agustin Barnadas, Danny Vesprini, Sara Gutiérrez-Enríquez, Meritxell Mollà, Orland Díez, John R. Yarnold, Jens Overgaard, Søren M. Bentzen, Jan Alsner, International Radiogenomics Consortium |
| Abstract |
Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium. The analysis included 5456 patients from 17 different cohorts. 2759 patients were given radiotherapy for breast cancer and 2697 for prostate cancer. Eight toxicity scores (overall toxicity, acute toxicity, late toxicity, acute skin toxicity, acute rectal toxicity, telangiectasia, fibrosis and late rectal toxicity) were analyzed. Adjustments were made for treatment and patient related factors with potential impact on the risk of toxicity. For all endpoints except late rectal toxicity, a significantly increased risk of toxicity was found for carriers of the minor (Asn) allele with odds of approximately 1.5 for acute toxicity and 1.2 for late toxicity. The results were consistent with a co-dominant pattern of inheritance. This study convincingly showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 33% |
| Denmark | 1 | 17% |
| Spain | 1 | 17% |
| United Kingdom | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 50% |
| Members of the public | 2 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 125 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 14% |
| Student > Ph. D. Student | 17 | 14% |
| Student > Master | 13 | 10% |
| Professor | 9 | 7% |
| Student > Bachelor | 8 | 6% |
| Other | 35 | 28% |
| Unknown | 25 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 38 | 30% |
| Biochemistry, Genetics and Molecular Biology | 22 | 18% |
| Physics and Astronomy | 7 | 6% |
| Nursing and Health Professions | 5 | 4% |
| Agricultural and Biological Sciences | 4 | 3% |
| Other | 14 | 11% |
| Unknown | 35 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2020.
All research outputs
#3,055,356
of 25,809,966 outputs
Outputs from Radiotherapy & Oncology
#483
of 4,924 outputs
Outputs of similar age
#53,133
of 380,535 outputs
Outputs of similar age from Radiotherapy & Oncology
#6
of 87 outputs
Altmetric has tracked 25,809,966 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,924 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 380,535 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.