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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection
|
|---|---|
| Published in |
EMBO Journal, September 2012
|
| DOI | 10.1038/emboj.2012.266 |
| Pubmed ID | |
| Authors |
Zhong Deng, Zhuo Wang, Nick Stong, Robert Plasschaert, Aliah Moczan, Horng‐Shen Chen, Sufeng Hu, Priyankara Wikramasinghe, Ramana V Davuluri, Marisa S Bartolomei, Harold Riethman, Paul M Lieberman |
| Abstract |
The contribution of human subtelomeric DNA and chromatin organization to telomere integrity and chromosome end protection is not yet understood in molecular detail. Here, we show by ChIP-Seq that most human subtelomeres contain a CTCF- and cohesin-binding site within ∼1-2 kb of the TTAGGG repeat tract and adjacent to a CpG-islands implicated in TERRA transcription control. ChIP-Seq also revealed that RNA polymerase II (RNAPII) was enriched at sites adjacent to the CTCF sites and extending towards the telomere repeat tracts. Mutation of CTCF-binding sites in plasmid-borne promoters reduced transcriptional activity in an orientation-dependent manner. Depletion of CTCF by shRNA led to a decrease in TERRA transcription, and a loss of cohesin and RNAPII binding to the subtelomeres. Depletion of either CTCF or cohesin subunit Rad21 caused telomere-induced DNA damage foci (TIF) formation, and destabilized TRF1 and TRF2 binding to the TTAGGG proximal subtelomere DNA. These findings indicate that CTCF and cohesin are integral components of most human subtelomeres, and important for the regulation of TERRA transcription and telomere end protection. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 201 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| France | 2 | <1% |
| Japan | 2 | <1% |
| United Kingdom | 1 | <1% |
| India | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 191 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 58 | 29% |
| Researcher | 46 | 23% |
| Student > Master | 30 | 15% |
| Student > Bachelor | 9 | 4% |
| Professor | 8 | 4% |
| Other | 22 | 11% |
| Unknown | 28 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 83 | 41% |
| Biochemistry, Genetics and Molecular Biology | 76 | 38% |
| Medicine and Dentistry | 3 | 1% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | <1% |
| Immunology and Microbiology | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 36 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2012.
All research outputs
#17,302,400
of 25,394,764 outputs
Outputs from EMBO Journal
#11,131
of 12,116 outputs
Outputs of similar age
#125,729
of 190,837 outputs
Outputs of similar age from EMBO Journal
#35
of 50 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,116 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 190,837 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.