Title |
Characterization of Blood Monocyte Phenotype in Patients With Endometrial Cancer
|
---|---|
Published in |
International Journal of Gynecological Cancer, May 2011
|
DOI | 10.1097/igc.0b013e3182249273 |
Pubmed ID | |
Authors |
Nicole Brooks, Lily Stojanovska, Peter Grant, Vasso Apostolopoulos, Christine F. McDonald, Dodie S. Pouniotis |
Abstract |
Endometrial tumors induce various tumor escape mechanisms that result in immunosuppression in patients and, ultimately, tumor progression. Blood monocytes are able to exhibit potent cytotoxic action against tumor cells where novel immunotherapeutics targeting antigen-presenting cells including dendritic cells, and blood monocytes are being used as a means of delivering immunogens to stimulate an antitumor and, ultimately, therapeutic response. This study shows that peripheral blood monocytes from patients with endometrial cancer show functional deficiencies, and these deficiencies can be characterized by phenotypic changes as well as altered cytokine secretion. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | 8% |
Belgium | 1 | 8% |
Unknown | 10 | 83% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 25% |
Student > Ph. D. Student | 3 | 25% |
Other | 2 | 17% |
Professor | 1 | 8% |
Student > Master | 1 | 8% |
Other | 1 | 8% |
Unknown | 1 | 8% |
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Medicine and Dentistry | 4 | 33% |
Agricultural and Biological Sciences | 2 | 17% |
Immunology and Microbiology | 2 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Unknown | 3 | 25% |