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Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation

Overview of attention for article published in Trends in Neurosciences, October 2012
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4 X users
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1 Facebook page

Citations

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135 Dimensions

Readers on

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224 Mendeley
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3 CiteULike
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Title
Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation
Published in
Trends in Neurosciences, October 2012
DOI 10.1016/j.tins.2012.09.003
Pubmed ID
Authors

Danay Baker-Andresen, Vikram S. Ratnu, Timothy W. Bredy

Abstract

DNA methylation was once considered to be a static epigenetic modification whose primary function was restricted to directing the development of cellular phenotype. However, it is now evident that the methylome is dynamically regulated across the lifespan: during development as a putative mechanism by which early experience leaves a lasting signature on the genome and during adulthood as a function of behavioral adaptation. Here, we propose that experience-dependent variations in DNA methylation, particularly within the context of learning and memory, represent a form of genomic metaplasticity that serves to prime the transcriptional response to later learning-related stimuli and neuronal reactivation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 224 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 3%
India 3 1%
United Kingdom 3 1%
Brazil 2 <1%
Austria 2 <1%
Japan 2 <1%
Canada 1 <1%
Mexico 1 <1%
Argentina 1 <1%
Other 5 2%
Unknown 198 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 56 25%
Student > Ph. D. Student 49 22%
Student > Bachelor 22 10%
Professor 20 9%
Student > Master 19 8%
Other 41 18%
Unknown 17 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 92 41%
Neuroscience 41 18%
Biochemistry, Genetics and Molecular Biology 17 8%
Medicine and Dentistry 16 7%
Psychology 16 7%
Other 17 8%
Unknown 25 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2013.
All research outputs
#15,739,529
of 25,374,647 outputs
Outputs from Trends in Neurosciences
#2,129
of 2,483 outputs
Outputs of similar age
#114,867
of 191,706 outputs
Outputs of similar age from Trends in Neurosciences
#11
of 16 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,483 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.1. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 191,706 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.