Title |
Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation
|
---|---|
Published in |
Trends in Neurosciences, October 2012
|
DOI | 10.1016/j.tins.2012.09.003 |
Pubmed ID | |
Authors |
Danay Baker-Andresen, Vikram S. Ratnu, Timothy W. Bredy |
Abstract |
DNA methylation was once considered to be a static epigenetic modification whose primary function was restricted to directing the development of cellular phenotype. However, it is now evident that the methylome is dynamically regulated across the lifespan: during development as a putative mechanism by which early experience leaves a lasting signature on the genome and during adulthood as a function of behavioral adaptation. Here, we propose that experience-dependent variations in DNA methylation, particularly within the context of learning and memory, represent a form of genomic metaplasticity that serves to prime the transcriptional response to later learning-related stimuli and neuronal reactivation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 25% |
Brazil | 1 | 25% |
Netherlands | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 3% |
India | 3 | 1% |
United Kingdom | 3 | 1% |
Brazil | 2 | <1% |
Austria | 2 | <1% |
Japan | 2 | <1% |
Canada | 1 | <1% |
Mexico | 1 | <1% |
Argentina | 1 | <1% |
Other | 5 | 2% |
Unknown | 198 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 56 | 25% |
Student > Ph. D. Student | 49 | 22% |
Student > Bachelor | 22 | 10% |
Professor | 20 | 9% |
Student > Master | 19 | 8% |
Other | 41 | 18% |
Unknown | 17 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 92 | 41% |
Neuroscience | 41 | 18% |
Biochemistry, Genetics and Molecular Biology | 17 | 8% |
Medicine and Dentistry | 16 | 7% |
Psychology | 16 | 7% |
Other | 17 | 8% |
Unknown | 25 | 11% |