| Title |
Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck
|
|---|---|
| Published in |
BMC Cancer, October 2012
|
| DOI | 10.1186/1471-2407-12-463 |
| Pubmed ID | |
| Authors |
Hanneke Stegeman, Johannes H Kaanders, Deric L Wheeler, Albert J van der Kogel, Marieke M Verheijen, Stijn J Waaijer, Mari Iida, Reidar Grénman, Paul N Span, Johan Bussink |
| Abstract |
Only a minority of cancer patients benefits from the combination of EGFR-inhibition and radiotherapy in head and neck squamous cell carcinoma (HNSCC). A potential resistance mechanism is activation of EGFR and/or downstream pathways by stimuli in the microenvironment. The aim of this study was to find molecular targets induced by the microenvironment by determining the in vitro and in vivo expression of proteins of the EGFR-signaling network in 6 HNSCC lines. As hypoxia is an important microenvironmental parameter associated with poor outcome in solid tumors after radiotherapy, we investigated the relationship with hypoxia in vitro and in vivo. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| France | 1 | 2% |
| Unknown | 48 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 24% |
| Student > Bachelor | 8 | 16% |
| Student > Ph. D. Student | 8 | 16% |
| Student > Master | 6 | 12% |
| Other | 4 | 8% |
| Other | 8 | 16% |
| Unknown | 4 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 28% |
| Medicine and Dentistry | 14 | 28% |
| Biochemistry, Genetics and Molecular Biology | 8 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 8% |
| Chemistry | 3 | 6% |
| Other | 3 | 6% |
| Unknown | 4 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2012.
All research outputs
#18,317,537
of 22,681,577 outputs
Outputs from BMC Cancer
#5,415
of 8,248 outputs
Outputs of similar age
#130,765
of 172,656 outputs
Outputs of similar age from BMC Cancer
#79
of 111 outputs
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