| Title |
Serrated polyps of the colon: how reproducible is their classification?
|
|---|---|
| Published in |
Virchows Archiv, October 2012
|
| DOI | 10.1007/s00428-012-1319-7 |
| Pubmed ID | |
| Authors |
Arzu Ensari, Banu Bilezikçi, Fatima Carneiro, Gülen Bülbül Doğusoy, Ann Driessen, Ayşe Dursun, Jean-François Flejou, Karel Geboes, Gert de Hertogh, Anne Jouret-Mourin, Cord Langner, Irıs D. Nagtegaal, Johan Offerhaus, Janina Orlowska, Ari Ristimäki, Julian Sanz-Ortega, Berna Savaş, Maria Sotiropoulou, Vincenzo Villanacci, Nazmiye Kurşun, Fred Bosman |
| Abstract |
For several years, the lack of consensus on definition, nomenclature, natural history, and biology of serrated polyps (SPs) of the colon has created considerable confusion among pathologists. According to the latest WHO classification, the family of SPs comprises hyperplastic polyps (HPs), sessile serrated adenomas/polyps (SSA/Ps), and traditional serrated adenomas (TSAs). The term SSA/P with dysplasia has replaced the category of mixed hyperplastic/adenomatous polyps (MPs). The present study aimed to evaluate the reproducibility of the diagnosis of SPs based on currently available diagnostic criteria and interactive consensus development. In an initial round, H&E slides of 70 cases of SPs were circulated among participating pathologists across Europe. This round was followed by a consensus discussion on diagnostic criteria. A second round was performed on the same 70 cases using the revised criteria and definitions according to the recent WHO classification. Data were evaluated for inter-observer agreement using Kappa statistics. In the initial round, for the total of 70 cases, a fair overall kappa value of 0.318 was reached, while in the second round overall kappa value improved to moderate (kappa = 0.557; p < 0.001). Overall kappa values for each diagnostic category also significantly improved in the final round, reaching 0.977 for HP, 0.912 for SSA/P, and 0.845 for TSA (p < 0.001). The diagnostic reproducibility of SPs improves when strictly defined, standardized diagnostic criteria adopted by consensus are applied. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 5 | 14% |
| Researcher | 5 | 14% |
| Student > Ph. D. Student | 4 | 11% |
| Professor > Associate Professor | 4 | 11% |
| Student > Postgraduate | 3 | 8% |
| Other | 9 | 24% |
| Unknown | 7 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 68% |
| Agricultural and Biological Sciences | 2 | 5% |
| Business, Management and Accounting | 1 | 3% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Neuroscience | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 7 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2012.
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#18,317,537
of 22,681,577 outputs
Outputs from Virchows Archiv
#1,527
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Outputs of similar age
#130,887
of 172,672 outputs
Outputs of similar age from Virchows Archiv
#17
of 27 outputs
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