| Title |
Delayed Anaphylaxis to Red Meat in Patients with IgE Specific for Galactose alpha-1,3-Galactose (alpha-gal)
|
|---|---|
| Published in |
Current Allergy and Asthma Reports, October 2012
|
| DOI | 10.1007/s11882-012-0315-y |
| Pubmed ID | |
| Authors |
Scott P. Commins, Thomas A. E. Platts-Mills |
| Abstract |
Anaphylaxis is a severe allergic reaction that can be rapidly progressing and fatal. In instances where the triggering allergen is not known, establishing the etiology of anaphylaxis is pivotal to long-term risk management. Our recent work has identified a novel IgE antibody (Ab) response to a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal), that has been associated with two distinct forms of anaphylaxis: (1) immediate onset anaphylaxis during first exposure to intravenous cetuximab, and (2) delayed onset anaphylaxis 3-6 h after ingestion of mammalian food products (e.g., beef and pork). The results of our studies strongly suggest that tick bites are a cause, if not the only significant cause, of IgE Ab responses to alpha-gal in the southern, eastern and central United States. Patients with IgE Ab to alpha-gal continue to emerge and, increasingly, these cases involve children. This IgE Ab response cross-reacts with cat and dog but does not appear to pose a risk for asthma; however, it may impair diagnostic testing in some situations. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 35% |
| Romania | 1 | 4% |
| United Kingdom | 1 | 4% |
| France | 1 | 4% |
| Australia | 1 | 4% |
| Brazil | 1 | 4% |
| Netherlands | 1 | 4% |
| Unknown | 9 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 61% |
| Practitioners (doctors, other healthcare professionals) | 5 | 22% |
| Scientists | 2 | 9% |
| Science communicators (journalists, bloggers, editors) | 2 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 131 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 17% |
| Researcher | 21 | 16% |
| Student > Master | 16 | 12% |
| Student > Bachelor | 16 | 12% |
| Other | 12 | 9% |
| Other | 24 | 18% |
| Unknown | 21 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 27% |
| Agricultural and Biological Sciences | 26 | 20% |
| Biochemistry, Genetics and Molecular Biology | 14 | 11% |
| Immunology and Microbiology | 8 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
| Other | 18 | 14% |
| Unknown | 24 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 116. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2024.
All research outputs
#368,240
of 25,744,802 outputs
Outputs from Current Allergy and Asthma Reports
#17
of 862 outputs
Outputs of similar age
#1,914
of 192,357 outputs
Outputs of similar age from Current Allergy and Asthma Reports
#1
of 23 outputs
Altmetric has tracked 25,744,802 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 862 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,357 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.