| Title |
Impact of Salinomycin on human cholangiocarcinoma: induction of apoptosis and impairment of tumor cell proliferation in vitro
|
|---|---|
| Published in |
BMC Cancer, October 2012
|
| DOI | 10.1186/1471-2407-12-466 |
| Pubmed ID | |
| Authors |
Thorsten Lieke, Wolf Ramackers, Sabine Bergmann, Jürgen Klempnauer, Michael Winkler, Johannes Klose |
| Abstract |
Cholangiocarcinoma (CC) is a primary liver cancer with increasing incidence worldwide. Despite all efforts made in past years, prognosis remains to be poor. At least in part, this might be explained by a pronounced resistance of CC cells to undergo apoptosis. Thus, new therapeutic strategies are imperatively required. In this study we investigated the effect of Salinomycin, a polyether ionophore antibiotic, on CC cells as an appropriate agent to treat CC. Salinomycin was quite recently identified to induce apoptosis in cancer stem cells and to overcome apoptosis-resistance in several leukemia-cells and other cancer cell lines of different origin. |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 23% |
| Student > Doctoral Student | 3 | 12% |
| Student > Master | 3 | 12% |
| Professor > Associate Professor | 3 | 12% |
| Researcher | 3 | 12% |
| Other | 5 | 19% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 31% |
| Agricultural and Biological Sciences | 5 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 12% |
| Biochemistry, Genetics and Molecular Biology | 3 | 12% |
| Veterinary Science and Veterinary Medicine | 2 | 8% |
| Other | 2 | 8% |
| Unknown | 3 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2012.
All research outputs
#20,169,675
of 22,681,577 outputs
Outputs from BMC Cancer
#6,480
of 8,248 outputs
Outputs of similar age
#153,431
of 172,686 outputs
Outputs of similar age from BMC Cancer
#108
of 111 outputs
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So far Altmetric has tracked 8,248 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 111 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.