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X Demographics
Mendeley readers
Attention Score in Context
| Title |
DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker
|
|---|---|
| Published in |
Carcinogenesis, October 2012
|
| DOI | 10.1093/carcin/bgs321 |
| Pubmed ID | |
| Authors |
Holger Heyn, F. Javier Carmona, Antonio Gomez, Humberto J. Ferreira, Jordana T. Bell, Sergi Sayols, Kirsten Ward, Olafur A. Stefansson, Sebastian Moran, Juan Sandoval, Jorunn E. Eyfjord, Tim D. Spector, Manel Esteller |
| Abstract |
Using whole blood from 15 twin pairs discordant for breast cancer and high-resolution (450K) DNA methylation analysis, we identified 403 differentially methylated CpG sites including known and novel potential breast cancer genes. Confirming the results in an independent validation cohort of 21 twin pairs determined the docking protein DOK7 as a candidate for blood-based cancer diagnosis. DNA hypermethylation of the promoter region was also seen in primary breast cancer tissues and cancer cell lines. Hypermethylation of DOK7 occurs years before tumor diagnosis, suggesting a role as a powerful epigenetic blood-based biomarker as well as providing insights into breast cancer pathogenesis. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 40% |
| South Africa | 1 | 20% |
| United States | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Uruguay | 2 | 1% |
| Germany | 1 | <1% |
| Brazil | 1 | <1% |
| Sweden | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 165 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 38 | 22% |
| Student > Ph. D. Student | 30 | 17% |
| Student > Master | 25 | 14% |
| Student > Bachelor | 14 | 8% |
| Professor | 10 | 6% |
| Other | 30 | 17% |
| Unknown | 26 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 57 | 33% |
| Biochemistry, Genetics and Molecular Biology | 35 | 20% |
| Medicine and Dentistry | 23 | 13% |
| Computer Science | 6 | 3% |
| Neuroscience | 5 | 3% |
| Other | 14 | 8% |
| Unknown | 33 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2014.
All research outputs
#12,861,953
of 22,681,577 outputs
Outputs from Carcinogenesis
#3,693
of 4,739 outputs
Outputs of similar age
#89,466
of 172,656 outputs
Outputs of similar age from Carcinogenesis
#27
of 42 outputs
Altmetric has tracked 22,681,577 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,739 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,656 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.