| Title |
Mucosal Immunology and Probiotics
|
|---|---|
| Published in |
Current Allergy and Asthma Reports, October 2012
|
| DOI | 10.1007/s11882-012-0313-0 |
| Pubmed ID | |
| Authors |
Maria Luisa Dongarrà, Valeria Rizzello, Letizia Muccio, Walter Fries, Antonio Cascio, Irene Bonaccorsi, Guido Ferlazzo |
| Abstract |
The cross-talk between the mucosa-associated immune system and microbiota is critical in mucosal tissue homeostasis as well as in protection against infectious and inflammatory diseases occurring at mucosal sites. This recent evidence has paved the way to therapeutic approaches aimed at modulating the mucosa-associated immune system using probiotics. Different strains of probiotics possess the ability to finely regulate dendritic cell (DC) activation, polarizing the subsequent T cell activity toward Th1 (e.g. Lactobacillus (Lb) acidophilus), Th2 (Lb.reuteri and Bifidobacterium bifidum) or, as more recently demonstrated, Th17 responses induced by specific strains such as Lb.rhamnosus GG and Lac23a, the latter isolated in our laboratory. Here, we review some recent advances in our understanding of probiotics effects on mucosal immunology, particularly on cells of the innate immunity such as DCs. We also highlight our own experiences in modulating DC functions by commensal bacteria and discuss the relevance of probiotics administration in the treatment of human immunopathologies. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | <1% |
| South Africa | 1 | <1% |
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 141 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 28 | 19% |
| Researcher | 24 | 16% |
| Student > Ph. D. Student | 17 | 12% |
| Student > Bachelor | 14 | 10% |
| Student > Doctoral Student | 14 | 10% |
| Other | 15 | 10% |
| Unknown | 35 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 21% |
| Medicine and Dentistry | 24 | 16% |
| Immunology and Microbiology | 18 | 12% |
| Biochemistry, Genetics and Molecular Biology | 13 | 9% |
| Chemistry | 3 | 2% |
| Other | 12 | 8% |
| Unknown | 46 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2013.
All research outputs
#13,137,473
of 22,681,577 outputs
Outputs from Current Allergy and Asthma Reports
#474
of 803 outputs
Outputs of similar age
#91,973
of 173,110 outputs
Outputs of similar age from Current Allergy and Asthma Reports
#16
of 22 outputs
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