| Title |
Transcriptional repression by YY1, a human GLI-Krüippel-related protein, and relief of repression by adenovirus E1A protein
|
|---|---|
| Published in |
Cell, October 1991
|
| DOI | 10.1016/0092-8674(91)90189-6 |
| Pubmed ID | |
| Authors |
Yang Shi, Edward Seto, Long-Sheng Chang, Thomas Shenk |
| Abstract |
A sequence within the transcription control region of the adeno-associated virus P5 promoter has been shown to mediate transcriptional activation by the adenovirus E1A protein. We report here that this same element mediates transcriptional repression in the absence of E1A. Two cellular proteins have been found to bind to overlapping regions within this sequence element. One of these proteins, YY1, is responsible for the repression. E1A relieves repression exerted by YY1 and further activates transcription through its binding site. A YY1-specific cDNA has been isolated. Its sequence reveals YY1 to be a zinc finger protein that belongs to the GLI-Krüppel gene family. The product of the cDNA binds to YY1 sites. When fused to the GAL4 DNA-binding domain, it is capable of repressing transcription directed by a promoter that contains GAL4-binding sites, and E1A proteins can relieve the repression and activate transcription through the fusion protein. |
Mendeley readers
The data shown below were compiled from readership statistics for 211 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Poland | 2 | <1% |
| Italy | 2 | <1% |
| United States | 2 | <1% |
| Germany | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 203 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 51 | 24% |
| Student > Master | 29 | 14% |
| Researcher | 25 | 12% |
| Student > Bachelor | 24 | 11% |
| Professor | 9 | 4% |
| Other | 28 | 13% |
| Unknown | 45 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 67 | 32% |
| Biochemistry, Genetics and Molecular Biology | 64 | 30% |
| Medicine and Dentistry | 10 | 5% |
| Neuroscience | 7 | 3% |
| Veterinary Science and Veterinary Medicine | 2 | <1% |
| Other | 14 | 7% |
| Unknown | 47 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2023.
All research outputs
#2,863,758
of 25,373,627 outputs
Outputs from Cell
#6,740
of 17,168 outputs
Outputs of similar age
#620
of 16,652 outputs
Outputs of similar age from Cell
#5
of 96 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,168 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.1. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 16,652 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.