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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Piwi and piRNAs Act Upstream of an Endogenous siRNA Pathway to Suppress Tc3 Transposon Mobility in the Caenorhabditis elegans Germline
|
|---|---|
| Published in |
Molecular Cell, June 2008
|
| DOI | 10.1016/j.molcel.2008.06.003 |
| Pubmed ID | |
| Authors |
Partha P. Das, Marloes P. Bagijn, Leonard D. Goldstein, Julie R. Woolford, Nicolas J. Lehrbach, Alexandra Sapetschnig, Heeran R. Buhecha, Michael J. Gilchrist, Kevin L. Howe, Rory Stark, Nik Matthews, Eugene Berezikov, René F. Ketting, Simon Tavaré, Eric A. Miska |
| Abstract |
The Piwi proteins of the Argonaute superfamily are required for normal germline development in Drosophila, zebrafish, and mice and associate with 24-30 nucleotide RNAs termed piRNAs. We identify a class of 21 nucleotide RNAs, previously named 21U-RNAs, as the piRNAs of C. elegans. Piwi and piRNA expression is restricted to the male and female germline and independent of many proteins in other small-RNA pathways, including DCR-1. We show that Piwi is specifically required to silence Tc3, but not other Tc/mariner DNA transposons. Tc3 excision rates in the germline are increased at least 100-fold in piwi mutants as compared to wild-type. We find no evidence for a Ping-Pong model for piRNA amplification in C. elegans. Instead, we demonstrate that Piwi acts upstream of an endogenous siRNA pathway in Tc3 silencing. These data might suggest a link between piRNA and siRNA function. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 328 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 3% |
| United Kingdom | 4 | 1% |
| Germany | 3 | <1% |
| France | 3 | <1% |
| Mexico | 2 | <1% |
| Brazil | 1 | <1% |
| Finland | 1 | <1% |
| Australia | 1 | <1% |
| Taiwan | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 300 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 78 | 24% |
| Researcher | 74 | 23% |
| Student > Master | 36 | 11% |
| Student > Bachelor | 31 | 9% |
| Professor > Associate Professor | 19 | 6% |
| Other | 55 | 17% |
| Unknown | 35 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 184 | 56% |
| Biochemistry, Genetics and Molecular Biology | 84 | 26% |
| Computer Science | 5 | 2% |
| Neuroscience | 4 | 1% |
| Engineering | 3 | <1% |
| Other | 10 | 3% |
| Unknown | 38 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2024.
All research outputs
#2,280,593
of 25,373,627 outputs
Outputs from Molecular Cell
#2,269
of 7,617 outputs
Outputs of similar age
#6,184
of 96,030 outputs
Outputs of similar age from Molecular Cell
#5
of 52 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,617 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.6. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,030 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.