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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Prebiotic‐supplemented partially hydrolysed cow's milk formula for the prevention of eczema in high‐risk infants: a randomized controlled trial
|
|---|---|
| Published in |
Allergy, February 2016
|
| DOI | 10.1111/all.12848 |
| Pubmed ID | |
| Authors |
R. J. Boyle, M. L.‐K. Tang, W. C. Chiang, M. C. Chua, I. Ismail, A. Nauta, J. O'B. Hourihane, P. Smith, M. Gold, J. Ziegler, J. Peake, P. Quinn, R. Rao, N. Brown, A. Rijnierse, J. Garssen, J. O. Warner, Christine Axelrad, Suzan Jeffries, Yvette Donald, Heather Barham, Jenny Brown, Rita Wickenden, Teresa Barnes, Simone Taylor, Susan Smith, Natalie Thomas, Anne Goh, Wong Anng Anng, Christy Cao Yu Hua, Deirdre Daly, Sinead Lafford, Claire Cullinane, Jacques Bindels, Liandre Merwe, Dineke Klaassen, Sophie Swinkels, Karen Knipping |
| Abstract |
Prevention guidelines for infants at high risk of allergic disease recommend hydrolysed formula if formula is introduced before 6 months, but evidence is mixed. Adding specific oligosaccharides may improve outcomes. To evaluate whether partially hydrolysed whey formula containing oligosaccharides (0.8 g/100 ml) (pHF-OS) can prevent eczema in high-risk infants [ISRCTN65195597]. We conducted a parallel-group, multicentre, randomized double-blind controlled trial of pHF-OS vs standard cow's milk formula. Infants with a family history of allergic disease were randomized (stratified by centre/maternal allergy) to active (n = 432) or control (n = 431) formula until 6 months of age if formula was introduced before 18 weeks. Primary outcome was cumulative incidence of eczema by 12 months in infants randomized at 0-4 weeks (375 pHF-OS, 383 control). Secondary outcomes were cumulative incidence of eczema by 12 or 18 months in all infants randomized, immune markers at 6 months and adverse events. Eczema occurred by 12 months in 84/293 (28.7%) infants allocated to pHF-OS at 0-4 weeks of age, vs 93/324 (28.7%) control (OR 0.98 95% CI 0.68, 1.40; P = 0.90), and 107/347 (30.8%) pHF-OS vs 112/370 (30.3%) control in all infants randomized (OR 0.99 95% CI 0.71, 1.37; P = 0.94). pHF-OS did not change most immune markers including total/specific IgE; however, pHF-OS reduced cow's milk-specific IgG1 (P < 0.0001) and increased regulatory T-cell and plasmacytoid dendritic cell percentages. There was no group difference in adverse events. pHF-OS does not prevent eczema in the first year in high-risk infants. The immunological changes found require confirmation in a separate cohort. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 40% |
| Kenya | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 40% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
| Scientists | 1 | 20% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 124 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 19% |
| Student > Bachelor | 21 | 17% |
| Student > Master | 10 | 8% |
| Student > Doctoral Student | 8 | 6% |
| Student > Ph. D. Student | 8 | 6% |
| Other | 19 | 15% |
| Unknown | 34 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 24% |
| Nursing and Health Professions | 15 | 12% |
| Agricultural and Biological Sciences | 12 | 10% |
| Biochemistry, Genetics and Molecular Biology | 8 | 6% |
| Immunology and Microbiology | 7 | 6% |
| Other | 14 | 11% |
| Unknown | 38 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2019.
All research outputs
#1,904,951
of 26,012,510 outputs
Outputs from Allergy
#697
of 5,587 outputs
Outputs of similar age
#29,525
of 313,306 outputs
Outputs of similar age from Allergy
#16
of 62 outputs
Altmetric has tracked 26,012,510 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,587 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.7. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,306 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.