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Emergence of Noise-Induced Oscillations in the Central Circadian Pacemaker

Overview of attention for article published in PLoS Biology, October 2010
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

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Title
Emergence of Noise-Induced Oscillations in the Central Circadian Pacemaker
Published in
PLoS Biology, October 2010
DOI 10.1371/journal.pbio.1000513
Pubmed ID
Authors

Caroline H. Ko, Yujiro R. Yamada, David K. Welsh, Ethan D. Buhr, Andrew C. Liu, Eric E. Zhang, Martin R. Ralph, Steve A. Kay, Daniel B. Forger, Joseph S. Takahashi

Abstract

Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, generates stochastic oscillations with periods that overlap the circadian range. Dissociated SCN neurons expressed fluctuating levels of PER2 detected by bioluminescence imaging but could not generate circadian oscillations intrinsically. Inhibition of intercellular communication or cyclic-AMP signaling in SCN slices, which provide a positive feed-forward signal to drive the intracellular negative feedback loop, abolished the stochastic oscillations. Propagation of this feed-forward signal between SCN neurons then promotes quasi-circadian oscillations that arise as an emergent property of the SCN network. Experimental analysis and mathematical modeling argue that both intercellular coupling and molecular noise are required for the stochastic rhythms, providing a novel biological example of noise-induced oscillations. The emergence of stochastic circadian oscillations from the SCN network in the absence of cell-autonomous circadian oscillatory function highlights a previously unrecognized level of circadian organization.

X Demographics

X Demographics

The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 260 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 5 2%
Germany 4 2%
United States 4 2%
Japan 3 1%
Chile 1 <1%
Sweden 1 <1%
Israel 1 <1%
Switzerland 1 <1%
Czechia 1 <1%
Other 3 1%
Unknown 236 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 71 27%
Researcher 58 22%
Professor > Associate Professor 19 7%
Student > Master 18 7%
Student > Bachelor 17 7%
Other 47 18%
Unknown 30 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 104 40%
Biochemistry, Genetics and Molecular Biology 31 12%
Neuroscience 17 7%
Medicine and Dentistry 14 5%
Mathematics 14 5%
Other 43 17%
Unknown 37 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2021.
All research outputs
#2,772,671
of 25,593,129 outputs
Outputs from PLoS Biology
#3,726
of 9,120 outputs
Outputs of similar age
#10,765
of 108,369 outputs
Outputs of similar age from PLoS Biology
#26
of 74 outputs
Altmetric has tracked 25,593,129 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,120 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.6. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,369 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.