| Title |
Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes
|
|---|---|
| Published in |
JAMA Psychiatry, March 2015
|
| DOI | 10.1001/jamapsychiatry.2014.2427 |
| Pubmed ID | |
| Authors |
Elaine Setiawan, Alan A. Wilson, Romina Mizrahi, Pablo M. Rusjan, Laura Miler, Grazyna Rajkowska, Ivonne Suridjan, James L. Kennedy, P. Vivien Rekkas, Sylvain Houle, Jeffrey H. Meyer |
| Abstract |
The neuroinflammatory hypothesis of major depressive disorder is supported by several main findings. First, in humans and animals, activation of the immune system causes sickness behaviors that present during a major depressive episode (MDE), such as low mood, anhedonia, anorexia, and weight loss. Second, peripheral markers of inflammation are frequently reported in major depressive disorder. Third, neuroinflammatory illnesses are associated with high rates of MDEs. However, a fundamental limitation of the neuroinflammatory hypothesis is a paucity of evidence of brain inflammation during MDE. Translocator protein density measured by distribution volume (TSPO VT) is increased in activated microglia, an important aspect of neuroinflammation. |
X Demographics
The data shown below were collected from the profiles of 97 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 25 | 26% |
| Canada | 9 | 9% |
| United Kingdom | 9 | 9% |
| France | 6 | 6% |
| Finland | 3 | 3% |
| Brazil | 2 | 2% |
| Netherlands | 2 | 2% |
| Antarctica | 1 | 1% |
| South Africa | 1 | 1% |
| Other | 4 | 4% |
| Unknown | 35 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 73 | 75% |
| Practitioners (doctors, other healthcare professionals) | 13 | 13% |
| Scientists | 10 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 618 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | <1% |
| Netherlands | 4 | <1% |
| Canada | 2 | <1% |
| Korea, Republic of | 1 | <1% |
| Mexico | 1 | <1% |
| Portugal | 1 | <1% |
| Unknown | 604 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 85 | 14% |
| Student > Master | 79 | 13% |
| Researcher | 72 | 12% |
| Student > Bachelor | 72 | 12% |
| Student > Doctoral Student | 45 | 7% |
| Other | 126 | 20% |
| Unknown | 139 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 114 | 18% |
| Medicine and Dentistry | 113 | 18% |
| Psychology | 56 | 9% |
| Agricultural and Biological Sciences | 53 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 24 | 4% |
| Other | 81 | 13% |
| Unknown | 177 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 501. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2023.
All research outputs
#52,481
of 25,837,817 outputs
Outputs from JAMA Psychiatry
#159
of 5,971 outputs
Outputs of similar age
#504
of 273,023 outputs
Outputs of similar age from JAMA Psychiatry
#2
of 55 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,971 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 70.8. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.