| Title |
A Synthetic Erectile Optogenetic Stimulator Enabling Blue‐Light‐Inducible Penile Erection
|
|---|---|
| Published in |
Angewandte Chemie. International Edition, March 2015
|
| DOI | 10.1002/anie.201412204 |
| Pubmed ID | |
| Authors |
Taeuk Kim, Marc Folcher, Marie Doaud‐El Baba, Martin Fussenegger |
| Abstract |
Precise spatiotemporal control of physiological processes by optogenetic devices inspired by synthetic biology may provide novel treatment opportunities for gene- and cell-based therapies. An erectile optogenetic stimulator (EROS), a synthetic designer guanylate cyclase producing a blue-light-inducible surge of the second messenger cyclic guanosine monophosphate (cGMP) in mammalian cells, enabled blue-light-dependent penile erection associated with occasional ejaculation after illumination of EROS-transfected corpus cavernosum in male rats. Photostimulated short-circuiting of complex psychological, neural, vascular, and endocrine factors to stimulate penile erection in the absence of sexual arousal may foster novel advances in the treatment of erectile dysfunction. |
X Demographics
The data shown below were collected from the profiles of 212 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 44 | 21% |
| United Kingdom | 14 | 7% |
| Germany | 10 | 5% |
| France | 9 | 4% |
| Canada | 6 | 3% |
| Switzerland | 5 | 2% |
| Japan | 5 | 2% |
| India | 4 | 2% |
| Spain | 3 | 1% |
| Other | 27 | 13% |
| Unknown | 85 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 140 | 66% |
| Scientists | 59 | 28% |
| Science communicators (journalists, bloggers, editors) | 9 | 4% |
| Practitioners (doctors, other healthcare professionals) | 3 | 1% |
| Unknown | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 170 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 4 | 2% |
| United States | 4 | 2% |
| Switzerland | 2 | 1% |
| United Kingdom | 2 | 1% |
| Sweden | 1 | <1% |
| Spain | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 155 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 27% |
| Researcher | 37 | 22% |
| Student > Master | 20 | 12% |
| Student > Bachelor | 14 | 8% |
| Student > Postgraduate | 8 | 5% |
| Other | 24 | 14% |
| Unknown | 21 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 43 | 25% |
| Chemistry | 36 | 21% |
| Biochemistry, Genetics and Molecular Biology | 28 | 16% |
| Engineering | 11 | 6% |
| Medicine and Dentistry | 10 | 6% |
| Other | 16 | 9% |
| Unknown | 26 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 339. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2022.
All research outputs
#98,707
of 25,729,842 outputs
Outputs from Angewandte Chemie. International Edition
#18
of 50,660 outputs
Outputs of similar age
#1,035
of 292,161 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#2
of 715 outputs
Altmetric has tracked 25,729,842 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 50,660 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,161 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 715 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.