Title |
THE EVOLUTION OF STRESS‐INDUCED HYPERMUTATION IN ASEXUAL POPULATIONS
|
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Published in |
Evolution, February 2012
|
DOI | 10.1111/j.1558-5646.2012.01576.x |
Pubmed ID | |
Authors |
Yoav Ram, Lilach Hadany |
Abstract |
Numerous empirical studies show that stress of various kinds induces a state of hypermutation in bacteria via multiple mechanisms, but theoretical treatment of this intriguing phenomenon is lacking. We used deterministic and stochastic models to study the evolution of stress-induced hypermutation in infinite and finite-size populations of bacteria undergoing selection, mutation, and random genetic drift in constant environments and in changing ones. Our results suggest that if beneficial mutations occur, even rarely, then stress-induced hypermutation is advantageous for bacteria at both the individual and the population levels and that it is likely to evolve in populations of bacteria in a wide range of conditions because it is favored by selection. These results imply that mutations are not, as the current view holds, uniformly distributed in populations, but rather that mutations are more common in stressed individuals and populations. Because mutation is the raw material of evolution, these results have a profound impact on broad aspects of evolution and biology. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Ecuador | 1 | 25% |
Israel | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
Belgium | 2 | 2% |
United Kingdom | 2 | 2% |
France | 1 | <1% |
Italy | 1 | <1% |
Switzerland | 1 | <1% |
Portugal | 1 | <1% |
Germany | 1 | <1% |
Israel | 1 | <1% |
Other | 1 | <1% |
Unknown | 107 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 37 | 31% |
Researcher | 18 | 15% |
Student > Master | 18 | 15% |
Student > Bachelor | 12 | 10% |
Student > Doctoral Student | 6 | 5% |
Other | 21 | 17% |
Unknown | 9 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 57 | 47% |
Biochemistry, Genetics and Molecular Biology | 23 | 19% |
Physics and Astronomy | 5 | 4% |
Immunology and Microbiology | 4 | 3% |
Medicine and Dentistry | 4 | 3% |
Other | 16 | 13% |
Unknown | 12 | 10% |