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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Human mesenchymal stem cells promote CD34+ hematopoietic stem cell proliferation with preserved red blood cell differentiation capacity
|
|---|---|
| Published in |
Cell Biology International, May 2017
|
| DOI | 10.1002/cbin.10774 |
| Pubmed ID | |
| Authors |
Show Xuan Lau, Yin Yee Leong, Wai Hoe Ng, Albert Wee Po Ng, Ida Shazrina Ismail, Narazah Mohd Yusoff, Rajesh Ramasamy, Jun Jie Tan |
| Abstract |
Studies showed that co-transplantation of mesenchymal stem cells (MSCs) and cord blood-derived CD34(+) hematopoietic stem cells (HSCs) offered greater therapeutic effects but little is known regarding the effects of human Wharton's jelly-derived MSCs on HSC expansion and red blood cell (RBC) generation in vitro. This study aimed to investigate the effects of MSCs on HSC expansion and differentiation. HSCs were co-cultured with MSCs or with 10% MSCs-derived conditioned medium, with HSCs cultured under standard medium served as a control. Cell expansion rates, number of mononuclear cell post-expansion and number of enucleated cells post-differentiation were evaluated. HSCs showed superior proliferation in the presence of MSC with mean expansion rate of 3.5 x 10(8) ± 1.8 x 10(7) after day 7 compared to the conditioned medium and the control group (8.9 x 10(7) ± 1.1 x 10(8) and 7.0 x 10(7) ± 3.3 x 10(6) respectively, p<0.001). Although no significant differences in RBC differentiation were observed between groups at passage IV, the number of enucleated cell were greater compared to earlier passages, indicating successful RBC differentiation. Cord blood-derived CD34(+) HSCs can be greatly expanded by co-culturing with MSCs without affecting the RBC differentiation capability, suggesting the importance of direct MSC-HSCs contact in HSC expansion and RBC differentiation. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 15% |
| Other | 2 | 7% |
| Student > Bachelor | 2 | 7% |
| Professor | 2 | 7% |
| Student > Doctoral Student | 1 | 4% |
| Other | 4 | 15% |
| Unknown | 12 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 15% |
| Immunology and Microbiology | 3 | 11% |
| Medicine and Dentistry | 2 | 7% |
| Agricultural and Biological Sciences | 2 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Other | 3 | 11% |
| Unknown | 12 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2021.
All research outputs
#6,770,729
of 24,578,676 outputs
Outputs from Cell Biology International
#163
of 1,159 outputs
Outputs of similar age
#100,452
of 315,386 outputs
Outputs of similar age from Cell Biology International
#4
of 21 outputs
Altmetric has tracked 24,578,676 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,159 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,386 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.