Title |
Effects of Ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf
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Published in |
Veterinary Parasitology, May 2002
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DOI | 10.1016/s0304-4017(02)00026-2 |
Pubmed ID | |
Authors |
M.T Fox, U.E Uche, C Vaillant, S Ganabadi, J Calam |
Abstract |
Infection with the bovine abomasal nematode, Ostertagia ostertagi, results in a loss of acid-secreting parietal cells and an increase in gastric pH. The effects of an experimental infection with Ostertagia and/or daily treatment with omeprazole (OMP) at 2mgkg(-1) bodyweight for four consecutive days (experiment days 24-27, inclusive) on voluntary feed intake, blood and tissue gastrin concentrations, abomasal G-cell numbers, gastric pH, and blood cholecystokinin (CCK) and pepsinogen concentrations were investigated in the calf. Ostertagia-infected calves demonstrated a significant drop in feed intake between days 24 and 27 post-infection (38%; P<0.001) and in G-cell numbers (42%; P<0.05) and significant increases in abomasal pH (P<0.001), fundic mucosal weight (99%; P<0.01), and blood gastrin (P<0.05) and pepsinogen (P<0.0001). OMP treatment of worm-free animals resulted in a significant drop in intake between days 24 and 27 (30%; P<0.001) and in G-cell numbers (17%; P<0.05) and significant increases in abomasal pH (P<0.01) and blood gastrin (P<0.001). OMP treatment of Ostertagia-infected animals with an existing hypergastrinaemia had no effect on feed intake, abomasal pH, blood gastrin or pepsinogen or abomasal G-cell numbers. Blood CCK concentrations were also unaffected by either Ostertagia infection or OMP treatment. These data suggest that: (a) the depression in feed intake associated with OMP in worm-free calves was not due to a side effect of drug treatment; (b) inappetance in Ostertagia-infected animals is closely associated with the parasite-induced hypergastrinaemia; and (c) the elevation in abomasal pH was a major factor responsible for the elevated blood gastrin concentrations seen in parasitised and OMP-treated animals. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 16% |
Professor > Associate Professor | 4 | 16% |
Other | 3 | 12% |
Researcher | 3 | 12% |
Student > Master | 2 | 8% |
Other | 3 | 12% |
Unknown | 6 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 36% |
Veterinary Science and Veterinary Medicine | 2 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Environmental Science | 1 | 4% |
Nursing and Health Professions | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 40% |