Title |
The TRPM2 channel nexus from oxidative damage to Alzheimer’s pathologies: An emerging novel intervention target for age-related dementia
|
---|---|
Published in |
Ageing Research Reviews, July 2018
|
DOI | 10.1016/j.arr.2018.07.002 |
Pubmed ID | |
Authors |
Lin-Hua Jiang, Xin Li, Sharifah A. Syed Mortadza, Megan Lovatt, Wei Yang |
Abstract |
Alzheimer's disease (AD), an age-related neurodegenerative condition, is the most common cause of dementia among the elder people, but currently there is no treatment. A number of putative pathogenic events, particularly amyloid β peptide (Aβ) accumulation, are believed to be early triggers that initiate AD. However, thus far targeting Aβ generation/aggregation as the mainstay strategy of drug development has not led to effective AD-modifying therapeutics. Oxidative damage is a conspicuous feature of AD, but this remains poorly defined phenomenon and mechanistically ill understood. The TRPM2 channel has emerged as a potentially ubiquitous molecular mechanism mediating oxidative damage and thus plays a vital role in the pathogenesis and progression of diverse neurodegenerative diseases. This article will review the emerging evidence from recent studies and propose a novel 'hypothesis' that multiple TRPM2-mediated cellular and molecular mechanisms cascade Aβ and/or oxidative damage to AD pathologies. The 'hypothesis' based on these new findings discusses the prospect of considering the TRPM2 channel as a novel therapeutic target for intervening AD and age-related dementia. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Belgium | 1 | 10% |
United Kingdom | 1 | 10% |
Argentina | 1 | 10% |
Mexico | 1 | 10% |
Austria | 1 | 10% |
Unknown | 5 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 60% |
Scientists | 4 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 19% |
Student > Ph. D. Student | 10 | 19% |
Student > Master | 3 | 6% |
Researcher | 3 | 6% |
Student > Doctoral Student | 2 | 4% |
Other | 5 | 10% |
Unknown | 19 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 23% |
Neuroscience | 5 | 10% |
Medicine and Dentistry | 4 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Chemistry | 2 | 4% |
Other | 8 | 15% |
Unknown | 18 | 35% |