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Mendeley readers
Attention Score in Context
| Title |
d-galactose and aluminium chloride induced rat model with cognitive impairments
|
|---|---|
| Published in |
Biomedicine & Pharmacotherapy, May 2018
|
| DOI | 10.1016/j.biopha.2018.04.152 |
| Pubmed ID | |
| Authors |
Samaila Musa Chiroma, Mohamad Aris Mohd Moklas, Che Norma Mat Taib, Mohamad Taufik Hidayat Baharuldin, Zulkhairi Amon |
| Abstract |
Cognitive impairments and cholinergic dysfunctions have been well reported in old age disorders including Alzheimer's disease (AD). d-galactose (D-gal) has been reported as a senescence agent while aluminium act as a neurotoxic metal, but little is known about their combined effects at different doses. The aim of this study was to establish an animal model with cognitive impairments by comparing the effects of different doses of co-administrated D-gal and aluminium chloride (AlCl3). In this study male albino wistar rats were administered with D-gal 60 mg/kg.bwt intra peritoneally (I.P) injected and AlCl3 (100, 200, or 300 mg/kg.bwt.) was orally administered once daily for 10 consecutive weeks. Performance of the rats were evaluated through behavioural assessments; Morris water maze (MWM) and open field tests (OFT); histopathological examination was performed on the hippocampus; moreover biochemical measurements of acetylcholinesterase (AChE) and hyperphosphorylated tau protein (p-tau) were examined. The results of this experiment on rats treated with D-gal 60 + AlCl3 200 mg/kg.bwt showed near ideal cognitive impairments. The rats exhibited an obvious memory and learning deficits, marked neuronal loss in hippocampus, showed increase in AChE activities and high expression of p-tau within the tissues of the brain. This study concludes that D-gal 60 + AlCl3 200 mg/kg.bwt as the ideal dose for mimicking AD like cognitive impairments in albino wistar rats. It is also crucial to understand the pathogenesis of this neurodegenerative disease and for drug discovery. |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 118 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 13% |
| Student > Master | 11 | 9% |
| Student > Bachelor | 9 | 8% |
| Researcher | 8 | 7% |
| Lecturer | 6 | 5% |
| Other | 18 | 15% |
| Unknown | 51 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 13% |
| Biochemistry, Genetics and Molecular Biology | 11 | 9% |
| Neuroscience | 10 | 8% |
| Immunology and Microbiology | 3 | 3% |
| Other | 11 | 9% |
| Unknown | 52 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2018.
All research outputs
#4,838,109
of 25,382,440 outputs
Outputs from Biomedicine & Pharmacotherapy
#878
of 6,545 outputs
Outputs of similar age
#87,422
of 341,525 outputs
Outputs of similar age from Biomedicine & Pharmacotherapy
#26
of 213 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,545 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,525 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 213 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.