You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Targets and mechanisms of berberine, a natural drug with potential to treat cancer with special focus on breast cancer
|
|---|---|
| Published in |
European Journal of Pharmacology, June 2014
|
| DOI | 10.1016/j.ejphar.2014.06.025 |
| Pubmed ID | |
| Authors |
Parham Jabbarzadeh Kaboli, Asmah Rahmat, Patimah Ismail, King-Hwa Ling |
| Abstract |
Breast cancer is the most common cancer among women worldwide and novel therapeutic agents are needed to treat this disease. The plant-based alkaloid berberine has potential therapeutic applications for breast cancer, although a better understanding of the genes and cellular pathways regulated by this compound is needed to define the mechanism of its action in cancer treatment. In this review, the molecular targets of berberine in various cancers, particularly breast cancer, are discussed. Berberine was shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells. Some signaling pathways affected by berberine, including the MAP (mitogen-activated protein) kinase and Wnt/β-catenin pathways, are critical for reducing cellular migration and sensitivity to various growth factors. This review will discuss recent studies and considers the application of new prospective approaches based on microRNAs and other crucial regulators for use in future studies to define the action of berberine in cancer. The effects of berberine on cancer cell survival and proliferation are also outlined. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Mexico | 1 | <1% |
| Spain | 1 | <1% |
| Lebanon | 1 | <1% |
| Unknown | 130 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 18% |
| Student > Master | 23 | 17% |
| Student > Bachelor | 19 | 14% |
| Researcher | 9 | 7% |
| Student > Doctoral Student | 8 | 6% |
| Other | 23 | 17% |
| Unknown | 29 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 22% |
| Agricultural and Biological Sciences | 22 | 16% |
| Medicine and Dentistry | 19 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 7% |
| Chemistry | 7 | 5% |
| Other | 13 | 10% |
| Unknown | 34 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2018.
All research outputs
#19,944,994
of 25,374,647 outputs
Outputs from European Journal of Pharmacology
#6,987
of 8,585 outputs
Outputs of similar age
#168,698
of 242,711 outputs
Outputs of similar age from European Journal of Pharmacology
#41
of 62 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,585 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,711 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.