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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model
|
|---|---|
| Published in |
Experimental Gerontology, April 2012
|
| DOI | 10.1016/j.exger.2012.03.018 |
| Pubmed ID | |
| Authors |
Hamoud Al Faqeh, Bin Mohamad Yahya Nor Hamdan, Hui Cheng Chen, Bin Saim Aminuddin, Bt Hj Idrus Ruszymah |
| Abstract |
In recent years, the use of bone marrow mesenchymal stem cell (BMSC) implantation has provided an alternative treatment for osteoarthritis. The objective of this study is to determine whether or not an intra-articular injection of a single dose of autologous chondrogenic induced BMSC could retard the progressive destruction of cartilage in a surgically induced osteoarthritis in sheep. Sheep BMSCs were isolated and divided into two groups. One group was cultured in chondrogenic media containing (Ham's F12:DMEM, 1:1) FD+1% FBS+5 ng/ml TGFβ3+50 ng/ml IGF-1 (CM), and the other group was cultured in the basal media, FD+10% FBS (BM). The procedure for surgically induced osteoarthritis was performed on the donor sheep 6 weeks prior to intra-articular injection into the knee joint of a single dose of BMSC from either group, suspended in 5 ml FD at density of 2 million cells/ml. The control groups were injected with basal media, without cells. Six weeks after injection, gross evidence of retardation of cartilage destruction was seen in the osteoarthritic knee joints treated with CM as well as BM. No significant ICRS (International Cartilage Repair Society) scoring was detected between the two groups with cells. However macroscopically, meniscus repair was observed in the knee joint treated with CM. Severe osteoarthritis and meniscal injury was observed in the control group. Interestingly, histologically the CM group demonstrated good cartilage histoarchitecture, thickness and quality, comparable to normal knee joint cartilage. As a conclusion, intra-articular injection of a single dose of BMSC either chondrogenically induced or not, could retard the progression of osteoarthritis (OA) in a sheep model, but the induced cells indicated better results especially in meniscus regeneration. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Portugal | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 162 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 16% |
| Researcher | 27 | 16% |
| Student > Master | 22 | 13% |
| Student > Bachelor | 19 | 11% |
| Student > Postgraduate | 13 | 8% |
| Other | 20 | 12% |
| Unknown | 38 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 57 | 34% |
| Agricultural and Biological Sciences | 22 | 13% |
| Biochemistry, Genetics and Molecular Biology | 14 | 8% |
| Engineering | 8 | 5% |
| Neuroscience | 4 | 2% |
| Other | 16 | 10% |
| Unknown | 45 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2014.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Experimental Gerontology
#2,085
of 2,796 outputs
Outputs of similar age
#113,204
of 174,012 outputs
Outputs of similar age from Experimental Gerontology
#17
of 22 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,796 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,012 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.