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Development and efficacy of feed-based recombinant vaccine encoding the cell wall surface anchor family protein of Streptococcus agalactiae against streptococcosis in Oreochromis sp.

Overview of attention for article published in Fish & Shellfish Immunology, January 2014
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  • Good Attention Score compared to outputs of the same age (71st percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

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1 policy source
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1 X user

Citations

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40 Dimensions

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76 Mendeley
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Title
Development and efficacy of feed-based recombinant vaccine encoding the cell wall surface anchor family protein of Streptococcus agalactiae against streptococcosis in Oreochromis sp.
Published in
Fish & Shellfish Immunology, January 2014
DOI 10.1016/j.fsi.2014.01.011
Pubmed ID
Authors

M. Nur-Nazifah, M.Y. Sabri, A. Siti-Zahrah

Abstract

This study was carried out to determine the antibody responses and protective capacity of an inactivated recombinant vaccine expressing the cell wall surface anchor family protein of Streptococcus agalactiae following oral vaccination against streptococcosis in tilapia. Tilapia were vaccinated orally with 10(6) CFU/mL of the recombinant vaccine incorporated in feed (feed-based recombinant vaccine) (vaccinated group or Group 1), 10(6) CFU/mL of pET-32 Ek/LIC vector without cell wall surface anchor family protein (control group or Group 2), 10(6) CFU/mL of formalin-killed cells of S. agalactiae vaccine incorporated in feed was also prepared (feed-based vaccine) (vaccinated group or Group 3), and unvaccinated control group or Group 4 (fed with commercial pellets). During the course of study, serum, mucus and gut lavage fluid were collected to evaluate the antibody levels via enzyme-linked immunosorbent assay (ELISA). The results showed that tilapia immunized with the feed-based recombinant vaccine developed a strong and significantly (P < 0.05) higher IgM antibody response in serum, mucus and gut lavage fluid samples compared to groups 2, 3 and 4. Following heat intervenes and intraperitoneal challenge, the rate of survivors (RPS) was 70% for the vaccinated group, and 0% for the rest of the groups. Therefore, the study revealed that the feed-based recombinant vaccine significantly provides high protection against high dose challenge in heat stress environment and enhances the production of the mucosal and humoral immunity.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 1%
South Africa 1 1%
Unknown 74 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 18%
Student > Master 9 12%
Student > Ph. D. Student 7 9%
Professor > Associate Professor 7 9%
Student > Bachelor 6 8%
Other 13 17%
Unknown 20 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 25%
Veterinary Science and Veterinary Medicine 7 9%
Biochemistry, Genetics and Molecular Biology 7 9%
Immunology and Microbiology 5 7%
Medicine and Dentistry 4 5%
Other 11 14%
Unknown 23 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2023.
All research outputs
#7,960,512
of 25,374,917 outputs
Outputs from Fish & Shellfish Immunology
#351
of 4,486 outputs
Outputs of similar age
#88,652
of 322,827 outputs
Outputs of similar age from Fish & Shellfish Immunology
#4
of 49 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,486 research outputs from this source. They receive a mean Attention Score of 1.4. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,827 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.