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Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome

Overview of attention for article published in Data in Brief, October 2014
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Title
Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome
Published in
Data in Brief, October 2014
DOI 10.1016/j.gdata.2014.09.009
Pubmed ID
Authors

Kai-Leng Tan, King-Hwa Ling, Chelsee A Hewitt, Pike-See Cheah, Ken Simpson, Lavinia Gordon, Melanie A Pritchard, Gordon K Smyth, Tim Thomas, Hamish S Scott

Abstract

The Ts1Cje mouse model of Down syndrome (DS) has partial trisomy of mouse chromosome 16 (MMU16), which is syntenic to human chromosome 21 (HSA21). It develops various neuropathological features demonstrated by DS patients such as reduced cerebellar volume [1] and altered hippocampus-dependent learning and memory [2,3]. To understand the global gene expression effect of the partially triplicated MMU16 segment on mouse brain development, we performed the spatiotemporal transcriptome analysis of Ts1Cje and disomic control cerebral cortex, cerebellum and hippocampus harvested at four developmental time-points: postnatal day (P)1, P15, P30 and P84. Here, we provide a detailed description of the experimental and analysis procedures of the microarray dataset, which has been deposited in the Gene Expression Omnibus (GSE49050) database.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 26%
Student > Master 4 21%
Student > Ph. D. Student 2 11%
Librarian 2 11%
Professor > Associate Professor 2 11%
Other 1 5%
Unknown 3 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 42%
Neuroscience 2 11%
Business, Management and Accounting 1 5%
Psychology 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Other 0 0%
Unknown 6 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2015.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Data in Brief
#2,935
of 3,678 outputs
Outputs of similar age
#227,154
of 265,584 outputs
Outputs of similar age from Data in Brief
#32
of 40 outputs
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