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Typhonium flagelliforme inhibits the proliferation of murine leukemia WEHI-3 cells in vitro and induces apoptosis in vivo

Overview of attention for article published in Leukemia Research, June 2010
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Title
Typhonium flagelliforme inhibits the proliferation of murine leukemia WEHI-3 cells in vitro and induces apoptosis in vivo
Published in
Leukemia Research, June 2010
DOI 10.1016/j.leukres.2010.04.023
Pubmed ID
Authors

Syam Mohan, Ahmad Bustamam Abdul, Siddig Ibrahim Abdelwahab, Adel S. Al-Zubairi, Mohamed Aspollah Sukari, Rasedee Abdullah, Manal Mohamed Elhassan Taha, Ng Kuan Beng, Nurbaity Mohd Isa

Abstract

Typhonium flagelliforme (TF) is a tropical plant, traditionally used by the ethnic population of Malaysia for the cure of various cancers. This plant had shown to induce antiproliferative effect as well as apoptosis in cancer cells. However, there is no available information to address that TF affects murine leukemia cells in vitro and in vivo. Here, we investigated in vitro and in vivo effects of TF on murine leukemia WEHI-3 cells. It was found that the growth of leukemia cells in vitro was inhibited by the various extracts of TF. Among these fractions, the dichloromethane (DCM) tuber extracts of TF showed the lowest IC(50) (24.0 ± 5.2 μg/ml) and had demonstrated apoptogenic effect when observed under fluorescent microscope. We investigated the in vivo effects of DCM tuber extracts of TF on murine leukemia cells, and the results showed that the counts of immature granulocytes and monocytes were significantly decreased in peripheral blood of BALB/c leukemia mice after the oral administration of DCM tuber extracts of TF for 28 days with three doses (200, 400 and 800 mg/kg). These results were confirmed by observing the spleen histopathology and morphology of enlarged spleen and liver in leukemia mice when compared with the control. Furthermore, the cell death mechanism in the spleen tissue of treated mice was found via apoptosis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 19%
Student > Master 7 15%
Researcher 7 15%
Student > Bachelor 4 8%
Professor > Associate Professor 3 6%
Other 6 13%
Unknown 12 25%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 7 15%
Biochemistry, Genetics and Molecular Biology 7 15%
Agricultural and Biological Sciences 6 13%
Medicine and Dentistry 4 8%
Immunology and Microbiology 2 4%
Other 6 13%
Unknown 16 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2014.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from Leukemia Research
#1,477
of 2,134 outputs
Outputs of similar age
#86,303
of 105,102 outputs
Outputs of similar age from Leukemia Research
#12
of 13 outputs
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.