Title |
Absorption and Bioavailability of Nano-Size Reduced Calcium Citrate Fortified Milk Powder in Ovariectomized and Ovariectomized-Osteoporosis Rats
|
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Published in |
Journal of Agricultural & Food Chemistry, June 2015
|
DOI | 10.1021/acs.jafc.5b01468 |
Pubmed ID | |
Authors |
Arezoo Erfanian, Hamed Mirhosseini, Babak Rasti, Mohd Hair-Bejo, Shuhaimi Bin Mustafa, Mohd Yazid Abd Manap |
Abstract |
The aim of this study was to evaluate the effects of fortification and nano size reduction on calcium absorption and bioavailability of milk powder formula in sham, ovariectomized and ovariectomized-osteoporosis rats as a menopause and menopause-osteoporosis model. Skim milk powder and skim milk powder fortified with calcium citrate and the suitable dose of inulin, EPA & DHA, vitamins D3, K1 and B6 were formulated based on the North American and West European recommended dietary allowances. Optimization on cycle and pressure of high-pressure homogenizer was done to produce nano fortified milk powder. In vivo study demonstrated that fortification and calcium citrate nano fortified milk powder increased absorption and bioavailability of calcium, as well as bone stiffness and bone strength in sham, ovariectomized and ovariectomized-osteoporosis rats. This study had successfully developed an effective fortified milk powder for food application. |
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