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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Potential of Dihydropyrimidine Dehydrogenase Genotypes in Personalizing 5-Fluorouracil Therapy Among Colorectal Cancer Patients
|
|---|---|
| Published in |
Therapeutic Drug Monitoring, October 2013
|
| DOI | 10.1097/ftd.0b013e318290acd2 |
| Pubmed ID | |
| Authors |
Lay Kek Teh, Sharina Hamzah, Hazwanie Hashim, Zakaria Bannur, Zainul Amiruddin Zakaria, Zakaria Hasbullani, John Kwong Siew Shia, Henry Fijeraid, Azmid Md Nor, Mohd Zailani, Prabu Ramasamy, Harris Ngow, Suneet Sood, Mohd Zaki Salleh |
| Abstract |
Dihydropyrimidine dehydrogenase (DPD) is a pyrimidine catabolic enzyme involved in the initial and rate-limiting step of the catabolic pathway of toxic metabolites of 5-fluorouracil (5-FU). Several studies have reported that deficiency of DPD and polymorphisms of its gene are related to 5-FU toxicities and death. Association between serum concentration of 5-FU and its related toxicity has also been previously demonstrated. Hence, this study aims to understand the role of DPYD variants in serum level of 5-FU and the risk of developing toxicity to prevent adverse reactions and maximize therapy outcome for personalized medicine. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 21% |
| Researcher | 9 | 13% |
| Student > Bachelor | 6 | 9% |
| Student > Ph. D. Student | 6 | 9% |
| Other | 5 | 7% |
| Other | 13 | 19% |
| Unknown | 15 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 24% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 18% |
| Agricultural and Biological Sciences | 10 | 15% |
| Biochemistry, Genetics and Molecular Biology | 7 | 10% |
| Immunology and Microbiology | 3 | 4% |
| Other | 3 | 4% |
| Unknown | 17 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2013.
All research outputs
#20,653,708
of 25,371,288 outputs
Outputs from Therapeutic Drug Monitoring
#1,388
of 1,787 outputs
Outputs of similar age
#166,049
of 219,838 outputs
Outputs of similar age from Therapeutic Drug Monitoring
#10
of 12 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,787 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 219,838 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.